Rv3774

Tuberculist information
Gene nameechA21
Protein functionPossible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)4218.85
Molecular mass(da)29101.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 274
	  		  	1    MGETYESVTVETKDQVAQVTLIGPGKGNAMGPAFWSEMPEVFHALDADREVRAIVITGSG   60
			  	61   KNFSYGLDVPAMGGMFAPLIADGALARPRTDFHTEILRMQKAINAVADCRTPTIAAVQGW  120
			  	121  CIGGAVDLISAVDIRYASADAKFSVREVKLAIVADMGSLARLPLILSDGHLRELALTGKN  180
			  	181  IDAARAEKIGLVNDVYDDADQTLAAAHATAAEIAANPPLAVYGIKDVLDQQRTSAVSENL  240
			  	241  RYVAAWNAAFLPSKDLTEGISATFAKRPPQFTGE

Known structures in the PDB
No Known structures
1 28 55 82 109 136 163 190 217 244 271 Range: 9 to 266  |  Coverage: 93% ECH Range: 4 to 271  |  Coverage: 97% 1 Range: 1 to 274  |  Coverage: 99% 1 Range: 215 to 274  |  Coverage: 21% 2
Number of amino acids : 274
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF003789-266
Mtb Structural Proteome models
Model Number1
Model nameRv3774
Template1DCI    APDBCREDO
Template coverage53_321
Template Identity(%)39.2
Model coverage(%)97.4
Normalized DOPE score-0.521

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore35.65
Residue begin1
Residue end274
Model Number2
Profile1.10.12.10
Click for model details
zscore14.82
Residue begin215
Residue end274
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3774Gene nameConfidence Score
Rv0244cfadE50.983
Rv0244cfadE50.983
Rv0244cfadE50.983
Rv0244cfadE50.983
Rv0244cfadE50.983
Rv2789cfadE210.978
Rv2789cfadE210.978
Rv2789cfadE210.978
Rv2500cfadE190.976
Rv2500cfadE190.976
Rv2500cfadE190.976
Rv2724cfadE200.975
Rv2724cfadE200.975
Rv2724cfadE200.975
Rv0975cfadE130.973
Rv0975cfadE130.973
Rv0975cfadE130.973
Rv0752cfadE90.971
Rv0752cfadE90.971
Rv0752cfadE90.971
Rv0215cfadE30.97
Rv0215cfadE30.97
Rv0215cfadE30.97
Rv0468fadB20.968
Rv0468fadB20.968
Rv3139fadE240.963
Rv3139fadE240.963
Rv3139fadE240.963
Rv3140fadE230.963
Rv3140fadE230.963
Rv0131cfadE10.943
Rv0131cfadE10.943
Rv0131cfadE10.943
Rv1715fadB30.939
Rv1715fadB30.939
Rv0860fadB0.931
Rv0860fadB0.931
Rv0860fadB0.931
Rv1550fadD110.92
Rv1467cfadE150.919
Rv1467cfadE150.919
Rv1467cfadE150.919
Rv1467cfadE150.919
Rv1467cfadE150.919
Rv0672fadE80.918
Rv0672fadE80.918
Rv1934cfadE170.913
Rv3560cfadE300.913
Rv3560cfadE300.913
Rv3560cfadE300.913
Rv3562fadE310.913
Rv1679fadE160.913
Rv3562fadE310.913
Rv1934cfadE170.913
Rv1679fadE160.913
Rv3562fadE310.913
Rv1934cfadE170.913
Rv1679fadE160.913
Rv3797fadE350.911
Rv3564fadE330.911
Rv3797fadE350.911
Rv1933cfadE180.911
Rv3564fadE330.911
Rv1933cfadE180.911
Rv0231fadE40.911
Rv0231fadE40.911
Rv0271cfadE60.909
Rv3505fadE270.909
Rv2502caccD10.909
Rv0271cfadE60.909
Rv0271cfadE60.909
Rv3505fadE270.909
Rv3274cfadE250.908
Rv3274cfadE250.908
Rv3274cfadE250.908
Rv3563fadE320.907
Rv3573cfadE340.907
Rv0154cfadE20.907
Rv3573cfadE340.907
Rv0154cfadE20.907
Rv3573cfadE340.907
Rv3563fadE320.907
Rv0154cfadE20.907
Rv3061cfadE220.906
Rv3061cfadE220.906
Rv3061cfadE220.906
Rv0400cfadE70.905
Rv0400cfadE70.905
Rv0400cfadE70.905
Rv3761cfadE360.904
Rv3543cfadE290.904
Rv3543cfadE290.904
Rv3543cfadE290.904
Rv3504fadE260.902
Rv3504fadE260.902
Rv3544cfadE280.902
Rv3504fadE260.902
Rv3544cfadE280.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.953835.608
coenzyme APubChem0.932767.534
NAD+PubChem0.923663.425
3-hydroxybutyryl-CoAPubChem0.903853.623
2-methylacetoacetyl-coenzyme APubChem0.9865.634
3-hydroxypropionyl-coenzyme APubChem0.9839.597
flavin adenine dinucleotidePubChem0.9785.55
C11945PubChem0.9917.752
C0885PubChem0.9917.752
trans-2-enoyl-CoAsPubChem0.9821.581
2-methylacetoacetyl-CoAPubChem0.9865.634
C01144PubChem0.9853.623
c0887PubChem0.9935.767
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
NSC112207PubChem0.9785.55
c1138PubChem0.9893.687
C05260PubChem0.9993.889
3-hydroxyadipyl-CoAPubChem0.9911.659
methacrylyl-CoAPubChem0.9835.608
C05271PubChem0.9863.661
2MCPubChem0.9835.608
CHEBI:15477PubChem0.9851.651
H(+)PubChem0.92.01588
3-hydroxydecanoyl-CoAPubChem0.9937.783
C05258PubChem0.91021.94
C05273PubChem0.9975.874
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C16469PubChem0.9893.687
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05268PubChem0.9881.677
C11947PubChem0.9935.767
C03221PubChem0.9947.821
methylcrotonyl CoAPubChem0.9849.635
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
acryloyl-CoAPubChem0.9821.581
alpha-methylbutyryl-CoAPubChem0.9851.651
C05989PubChem0.9837.581
1,5-dihydro-FADPubChem0.9787.566
C14145PubChem0.9911.659
c1137PubChem0.9875.672
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methylbutyryl-CoAPubChem0.9851.651
FADH2PubChem0.9787.566
C05275PubChem0.9919.768
isobutyryl-CoAPubChem0.9837.624
C11946PubChem0.9917.752
AR-1A9122PubChem0.9787.566
C05262PubChem0.9965.836
3-methylcrotonyl-CoAPubChem0.9849.635
C04405PubChem0.9867.65
trans-2-hexadecenoyl-CoAPubChem0.91003.93
C16468PubChem0.9875.672
AR-1H5729PubChem0.9835.608
C05266PubChem0.9909.73
3-hydroxypropionyl-CoAPubChem0.9839.597
C05276PubChem0.9891.714
hydroxyl radicalsPubChem0.917.0073
CHEBI:15489PubChem0.9837.581
Co-APubChem0.9767.534