Rv1679

Tuberculist information
Gene namefadE16
Protein functionPossible acyl-CoA dehydrogenase FadE16
Functional category(tuberculist)lipid metabolism
Gene location(kb)1903.3
Molecular mass(da)37876.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 373
	  		  	1    MATPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLVLPREIGGMGSGPVEFT   60
			  	61   EVVAQLSAACGSTAMIYLMHMAAAVTVAASPPPGLPDLLADMASGKQLGTLAFSEPGSRS  120
			  	121  HFWAPVSTASADGDGIAVRADKSWVTSAGFADVYVVSVGSADGAAGDVDLYAVPADTPGL  180
			  	181  RVAGTFTGMGLRGNASAPMAVDIRIPDSYRLGEAGGGFGIMMQTVLPWFNLGNAAVSLGL  240
			  	241  ATAATGAAVKHVGTARLEHLGGSLAELPTIRAQIARMGTTLAAQKAYLEVAANSVSSPDD  300
			  	301  TTLTHVLGVKASVNDAALTITESAMRVCGGAAFSKHLPIERAFRDARAGSVMAPTADALY  360
			  	361  DFYGRAVTGLPLF

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 5 to 106  |  Coverage: 27% Acyl-CoA_dh_N Range: 110 to 162  |  Coverage: 13% Acyl-CoA_dh_M Range: 215 to 367  |  Coverage: 40% Acyl-CoA_dh_1 Range: 3 to 368  |  Coverage: 97% 1 Range: 1 to 373  |  Coverage: 99% 1 Range: 214 to 373  |  Coverage: 42% 2 Range: 97 to 227  |  Coverage: 34% 3 Range: 5 to 106  |  Coverage: 27% 4 Range: 110 to 162  |  Coverage: 13% 5 Range: 1 to 350  |  Coverage: 93% 6
Number of amino acids : 373
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027715-106
Acyl-CoA_dh_MPF02770110-162
Acyl-CoA_dh_1PF00441215-367
Mtb Structural Proteome models
Model Number1
Model nameRv1679
Template1JQI    APDBCREDO
Template coverage22_383
Template Identity(%)26.2
Model coverage(%)97.9
Normalized DOPE score-0.461

Structure Models from Chopin
Model Number1
Profilea.29.3.1, e.6.1.1 - 1.10.540.10, 1.20.140.10, 2.40.110.10
Click for model details
zscore56.44
Residue begin1
Residue end373
Model Number2
Profilea.29.3.1
Click for model details
zscore29.07
Residue begin214
Residue end373
Model Number3
Profile2.40.110.10
Click for model details
zscore15.78
Residue begin97
Residue end227
Model Number4
Profile1.10.540.10
Click for model details
zscore14.16
Residue begin5
Residue end106
Model Number5
Profilee.6.1.1
Click for model details
zscore13.24
Residue begin110
Residue end162
Model Number6
Profilee.6.1.1
Click for model details
zscore11.62
Residue begin1
Residue end350
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1679Gene nameConfidence Score
Rv1680Rv16800.982
Rv0456cechA20.942
Rv1071cechA90.941
Rv1071cechA90.941
Rv2679echA150.94
Rv1935cechA130.937
Rv0675echA50.937
Rv1141cechA110.934
Rv0673echA40.934
Rv2831echA160.933
Rv3550echA200.931
Rv1142cechA100.93
Rv0971cechA70.93
Rv0222echA10.928
Rv0632cechA30.928
Rv3516echA190.918
Rv0860fadB0.917
Rv0860fadB0.917
Rv0860fadB0.917
Rv3774echA210.913
Rv1070cechA80.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
c1137PubChem0.9875.672
C16468PubChem0.9875.672
5-methylhex-4-enoyl-CoAPubChem0.9877.688