Rv0632c

Tuberculist information
Gene nameechA3
Protein functionProbable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)728.583
Molecular mass(da)24354.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 231
	  		  	1    MSDPVSYTRKDSIAVISMDDGKVNALGPAMQQALNAAIDNADRDDVGALVITGNGRVFSG   60
			  	61   GFDLKILTSGEVQPAIDMLRGGFELAYRLLSYPKPVVMACTGHAIAMGAFLLSCGDHRVA  120
			  	121  AHAYNIQANEVAIGMTIPYAALEIMKLRLTRSAYQQATGLAKTFFGETALAAGFIDEIAL  180
			  	181  PEVVVSRAEEAAREFAGLNQHAHAATKLRSRADALTAIRAGIDGIAAEFGL

Known structures in the PDB
No Known structures
1 24 47 70 93 116 139 162 185 208 231 Range: 6 to 223  |  Coverage: 93% ECH Range: 5 to 230  |  Coverage: 97% 1 Range: 1 to 231  |  Coverage: 99% 1
Number of amino acids : 231
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF003786-223
Mtb Structural Proteome models
Model Number1
Model nameRv0632c
Template1XX4    APDBCREDO
Template coverage34_265
Template Identity(%)20.8
Model coverage(%)97.4
Normalized DOPE score-0.548

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore32.63
Residue begin1
Residue end231
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0632cGene nameConfidence Score
Rv0860fadB0.94
Rv0468fadB20.94
Rv1550fadD110.94
Rv0468fadB20.94
Rv0860fadB0.94
Rv0860fadB0.94
Rv1715fadB30.935
Rv1715fadB30.935
Rv3505fadE270.935
Rv3505fadE270.935
Rv1934cfadE170.928
Rv3562fadE310.928
Rv1933cfadE180.928
Rv3562fadE310.928
Rv1933cfadE180.928
Rv1679fadE160.928
Rv3562fadE310.928
Rv1934cfadE170.928
Rv1679fadE160.928
Rv1934cfadE170.928
Rv1679fadE160.928
Rv0154cfadE20.922
Rv0154cfadE20.922
Rv0154cfadE20.922
Rv3564fadE330.921
Rv3564fadE330.921
Rv0271cfadE60.92
Rv1467cfadE150.92
Rv0271cfadE60.92
Rv0131cfadE10.92
Rv1467cfadE150.92
Rv0271cfadE60.92
Rv0131cfadE10.92
Rv1467cfadE150.92
Rv0131cfadE10.92
Rv0231fadE40.92
Rv1467cfadE150.92
Rv0231fadE40.92
Rv1467cfadE150.92
Rv3560cfadE300.919
Rv3543cfadE290.919
Rv3560cfadE300.919
Rv3543cfadE290.919
Rv3543cfadE290.919
Rv3563fadE320.919
Rv3560cfadE300.919
Rv3563fadE320.919
Rv3504fadE260.917
Rv3504fadE260.917
Rv3504fadE260.917
Rv0975cfadE130.916
Rv0975cfadE130.916
Rv0975cfadE130.916
Rv3544cfadE280.916
Rv3544cfadE280.916
Rv0215cfadE30.912
Rv0215cfadE30.912
Rv0215cfadE30.912
Rv3139fadE240.91
Rv3139fadE240.91
Rv3139fadE240.91
Rv2502caccD10.907
Rv3028cfixB0.903
Rv3028cfixB0.903
Rv3029cfixA0.902
Rv0243fadA20.901
Rv0244cfadE50.901
Rv0244cfadE50.901
Rv0244cfadE50.901
Rv0244cfadE50.901
Rv0244cfadE50.901
Rv0243fadA20.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C05275PubChem0.9919.768
crotonyl-CoAPubChem0.9835.608
C11945PubChem0.9917.752
c1137PubChem0.9875.672
C05260PubChem0.9993.889
[(2S,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[[[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[2-(1-oPubChem0.9833.592
acryloyl-CoAPubChem0.9821.581
trans-2-hexadecenoyl-CoAPubChem0.91003.93
2MCPubChem0.9835.608
protiumPubChem0.92.01576
3-trans-decenoyl-CoAPubChem0.9919.768
3-hydroxydecanoyl-CoAPubChem0.9937.783
acetoacetyl-CoAPubChem0.9851.607
methacrylyl-CoAPubChem0.9835.608
C05276PubChem0.9891.714
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
CHEBI:28002PubChem0.9945.805
C05268PubChem0.9881.677
3-methylcrotonyl-CoAPubChem0.9849.635
C05258PubChem0.91021.94
C05280PubChem0.9945.805
methylcrotonyl CoAPubChem0.9849.635
C16468PubChem0.9875.672
acetoacetyl-S-CoAPubChem0.9851.607
c0887PubChem0.9935.767
3-hydroxybutyryl-CoAPubChem0.9853.623
C11947PubChem0.9935.767
C0885PubChem0.9917.752
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
trans-2-decenoyl-coenzyme APubChem0.9919.768
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05271PubChem0.9863.661
deuteriumPubChem0.92.01588
C14145PubChem0.9911.659
c1138PubChem0.9893.687
C05262PubChem0.9965.836
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
C01144PubChem0.9853.623
C05273PubChem0.9975.874
NAD+PubChem0.9663.425
C11946PubChem0.9917.752
C05266PubChem0.9909.73
3-hydroxyadipyl-CoAPubChem0.9911.659
C04405PubChem0.9867.65
C05279PubChem0.9945.805
hydroxyl radicalsPubChem0.917.0073
CHEBI:28387PubChem0.9945.805
3-hydroxypropionyl-coenzyme APubChem0.9839.597
butyryl-CoAPubChem0.9837.624
3-hydroxypropionyl-CoAPubChem0.9839.597
C03221PubChem0.9947.821
trans-2-enoyl-CoAsPubChem0.9821.581
C16469PubChem0.9893.687
H(+)PubChem0.92.01588