Rv3139

Tuberculist information
Gene namefadE24
Protein functionProbable acyl-CoA dehydrogenase FadE24
Functional category(tuberculist)lipid metabolism
Gene location(kb)3505.36
Molecular mass(da)49646.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 468
	  		  	1    MTNTTSAANAAKPSGARTDRRGRTTGVGLAPHKRTGIDVALALLTPIVGQEFLDKYRLRD   60
			  	61   PLNRSLRYGVKTMFATAGAATRQFQRVQGLRGGPTRLKSSGRDYFDLTPDDDQKLIIETV  120
			  	121  DEFAEEVLRPAAHDADDAATYPSDLTAKAAELGITAINIPEDFDGIAEHRSSVTNVLVAE  180
			  	181  ALAYGDMGLALPILAPGGVASALTHWGSADQQATYLKEFAGENVPQACVAITEPQPLFDP  240
			  	241  TRLKTTAVRTPSGYRLDGVKSLIPAAADAELFIVGAQLGGKPALFIVESAASGLTVKADP  300
			  	301  SMGIRGAALGQVELCGVSVPLNARLGEDEASDNDYSEALALARLGWAALAVGTSHAVLDY  360
			  	361  VVPYVKQRQAFGEPIAHRQAVAFMCANIAIELDGLRLITWRGASRAEQGLPFAREAALAK  420
			  	421  RLGSDKGMQIGLDGVQLLGGHGYTKEHPVERWYRDLRAIGVAEGVVVI

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 110 to 222  |  Coverage: 23% Acyl-CoA_dh_N Range: 228 to 280  |  Coverage: 11% Acyl-CoA_dh_M Range: 334 to 466  |  Coverage: 28% Acyl-CoA_dh_1 Range: 106 to 468  |  Coverage: 77% 1 Range: 94 to 468  |  Coverage: 79% 1 Range: 334 to 466  |  Coverage: 28% 2 Range: 110 to 222  |  Coverage: 23% 3 Range: 190 to 341  |  Coverage: 32% 4 Range: 228 to 280  |  Coverage: 11% 5 Range: 64 to 233  |  Coverage: 36% 6 Range: 97 to 332  |  Coverage: 50% 7
Number of amino acids : 468
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF02771110-222
Acyl-CoA_dh_MPF02770228-280
Acyl-CoA_dh_1PF00441334-466
Mtb Structural Proteome models
Model Number1
Model nameRv3139
Template1UKW    APDBCREDO
Template coverage33_398
Template Identity(%)30.9
Model coverage(%)77.4
Normalized DOPE score-0.774

Structure Models from Chopin
Model Number1
Profile1.10.540.10, 2.40.110.10
Click for model details
zscore67.32
Residue begin94
Residue end468
Model Number2
Profilea.29.3.1
Click for model details
zscore34.53
Residue begin334
Residue end466
Model Number3
Profile1.10.540.10
Click for model details
zscore16.79
Residue begin110
Residue end222
Model Number4
Profile2.40.110.10
Click for model details
zscore16.3
Residue begin190
Residue end341
Model Number5
Profilee.6.1.1
Click for model details
zscore13.4
Residue begin228
Residue end280
Model Number6
Profile1.10.540.10
Click for model details
zscore12.45
Residue begin64
Residue end233
Model Number7
Profilee.6.1.1
Click for model details
zscore12.13
Residue begin97
Residue end332
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3139Gene nameConfidence Score
Rv3774echA210.963
Rv3140fadE230.92
Rv0166fadD50.92
Rv0166fadD50.92
Rv3140fadE230.92
Rv0860fadB0.913
Rv0860fadB0.913
Rv0860fadB0.913
Rv0675echA50.912
Rv0905echA60.911
Rv1070cechA80.91
Rv0632cechA30.91
Rv3561fadD30.903
Rv3561fadD30.903
Rv3551Rv35510.902
Rv3552Rv35520.902
Rv1071cechA90.902
Rv1071cechA90.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.915785.55
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
adenosine monophosphatePubChem0.9347.221