Rv0675

Tuberculist information
Gene nameechA5
Protein functionProbable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)774.783
Molecular mass(da)27441.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 263
	  		  	1    MSDLVRVERKGRVTTVILNRPASRNAVNGPTAAALCAAFEQFDRDDAASVAVLWGAGGTF   60
			  	61   CAGADLKAFGTPEANSVHRTGPGPMGPSRMMLSKPVIAAVSGYAVAGGLELALWCDLRVA  120
			  	121  EEDAVFGVFCRRWGVPLIDGGTVRLPRLIGHSRAMDMILTGRGVPADEALAMGLANRVVP  180
			  	181  KGQARQAAEELAAQLAALPQQCLRSDRLSALHQWGLPESAALDLEFASIARVAGEALEGA  240
			  	241  RRFAAGAGRHGAPAPRAEQGDTL

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 6 to 239  |  Coverage: 88% ECH Range: 4 to 250  |  Coverage: 93% 1 Range: 1 to 263  |  Coverage: 99% 1
Number of amino acids : 263
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF003786-239
Mtb Structural Proteome models
Model Number1
Model nameRv0675
Template1UIY    APDBCREDO
Template coverage1_252
Template Identity(%)36.4
Model coverage(%)93.5
Normalized DOPE score0.123

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore35.28
Residue begin1
Residue end263
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0675Gene nameConfidence Score
Rv1715fadB30.959
Rv1715fadB30.959
Rv0468fadB20.955
Rv0468fadB20.955
Rv1934cfadE170.943
Rv1934cfadE170.943
Rv1934cfadE170.943
Rv0131cfadE10.942
Rv0131cfadE10.942
Rv0131cfadE10.942
Rv1679fadE160.937
Rv3562fadE310.937
Rv1933cfadE180.937
Rv1933cfadE180.937
Rv1679fadE160.937
Rv3562fadE310.937
Rv1679fadE160.937
Rv3562fadE310.937
Rv1467cfadE150.936
Rv3140fadE230.936
Rv1467cfadE150.936
Rv1467cfadE150.936
Rv1467cfadE150.936
Rv1467cfadE150.936
Rv3140fadE230.936
Rv0231fadE40.934
Rv0231fadE40.934
Rv3564fadE330.934
Rv3564fadE330.934
Rv3505fadE270.931
Rv0271cfadE60.931
Rv3505fadE270.931
Rv0271cfadE60.931
Rv0271cfadE60.931
Rv0154cfadE20.93
Rv3563fadE320.93
Rv3560cfadE300.93
Rv3563fadE320.93
Rv3560cfadE300.93
Rv3543cfadE290.93
Rv3560cfadE300.93
Rv3543cfadE290.93
Rv0154cfadE20.93
Rv3543cfadE290.93
Rv0154cfadE20.93
Rv3504fadE260.928
Rv3504fadE260.928
Rv3504fadE260.928
Rv3544cfadE280.923
Rv3544cfadE280.923
Rv0860fadB0.915
Rv0860fadB0.915
Rv0860fadB0.915
Rv3139fadE240.912
Rv3139fadE240.912
Rv3139fadE240.912
Rv0244cfadE50.91
Rv0244cfadE50.91
Rv0244cfadE50.91
Rv0244cfadE50.91
Rv0244cfadE50.91
Rv2502caccD10.909
Rv3761cfadE360.904
Rv0400cfadE70.903
Rv0400cfadE70.903
Rv0400cfadE70.903
Rv3274cfadE250.901
Rv3274cfadE250.901
Rv3274cfadE250.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.906835.608
3-hydroxybutyryl-CoAPubChem0.902853.623
AR-1A9122PubChem0.9787.566
C0885PubChem0.9917.752
methylcrotonyl CoAPubChem0.9849.635
C16468PubChem0.9875.672
c0887PubChem0.9935.767
flavin adenine dinucleotidePubChem0.9785.55
3-hydroxypropionyl-CoAPubChem0.9839.597
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
C05271PubChem0.9863.661
deuteriumPubChem0.92.01588
C11945PubChem0.9917.752
C01144PubChem0.9853.623
C05262PubChem0.9965.836
2-methylbutyryl-CoAPubChem0.9851.651
2-methylacetoacetyl-coenzyme APubChem0.9865.634
C05273PubChem0.9975.874
NAD+PubChem0.9663.425
protiumPubChem0.92.01576
C05266PubChem0.9909.73
3-methylcrotonyl-CoAPubChem0.9849.635
methacrylyl-CoAPubChem0.9835.608
NSC112207PubChem0.9785.55
C03221PubChem0.9947.821
hydroxyl radicalsPubChem0.917.0073
CHEBI:15477PubChem0.9851.651
3-hydroxypropionyl-coenzyme APubChem0.9839.597
C05258PubChem0.91021.94
H(+)PubChem0.92.01588
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C16469PubChem0.9893.687
C05275PubChem0.9919.768
1,5-dihydro-FADPubChem0.9787.566
C11947PubChem0.9935.767
acryloyl-CoAPubChem0.9821.581
C05260PubChem0.9993.889
2-methylacetoacetyl-CoAPubChem0.9865.634
trans-2-hexadecenoyl-CoAPubChem0.91003.93
2MCPubChem0.9835.608
C14145PubChem0.9911.659
FADH2PubChem0.9787.566
3-hydroxydecanoyl-CoAPubChem0.9937.783
3-hydroxyadipyl-CoAPubChem0.9911.659
alpha-methylbutyryl-CoAPubChem0.9851.651
C05276PubChem0.9891.714
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C11946PubChem0.9917.752
C05268PubChem0.9881.677
C04405PubChem0.9867.65