Rv3543c

Tuberculist information
Gene namefadE29
Protein functionProbable acyl-CoA dehydrogenase FadE29
Functional category(tuberculist)lipid metabolism
Gene location(kb)3981.98
Molecular mass(da)42715.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 387
	  		  	1    MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRHGPAYRAVIRRMGRDGRLGVGWPK   60
			  	61   EFGGLGFGPIEQQIFVNEAHRADVPLPAVTLQTVGPTLQAHGSELQKKKFLPAILAGEAH  120
			  	121  FAIGYTEPEAGTDLASLRTTAVRDGDHYIVNGQKVFTTGAHDADYIWLACRTDPNAAKHK  180
			  	181  GISILIVDTKDPGYSWTPIILADGAHHTNATYYNDVRVPVDMLVGKENDGWRLITTQLNN  240
			  	241  ERVMLGPAGRFASIYDRVHAWASVPGGNGVTPIDHDDVKRALGEIRAIWRINELLNWQVA  300
			  	301  SAGEDINMADAAATKVFGTERVQRAGRLAEEIVGKYGNPAEPDTAELLRWLDAQTKRNLV  360
			  	361  ITFGGGVNEVMREMIAASGLKVPRVPR

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 6 to 118  |  Coverage: 28% Acyl-CoA_dh_N Range: 122 to 173  |  Coverage: 13% Acyl-CoA_dh_M Range: 228 to 380  |  Coverage: 39% Acyl-CoA_dh_1 Range: 3 to 382  |  Coverage: 97% 1 Range: 1 to 387  |  Coverage: 99% 1 Range: 228 to 380  |  Coverage: 39% 2 Range: 6 to 118  |  Coverage: 28% 3 Range: 111 to 240  |  Coverage: 33% 4 Range: 1 to 231  |  Coverage: 59% 5
Number of amino acids : 387
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027716-118
Acyl-CoA_dh_MPF02770122-173
Acyl-CoA_dh_1PF00441228-380
Mtb Structural Proteome models
Model Number1
Model nameRv3543c
Template1RX0    APDBCREDO
Template coverage17_393
Template Identity(%)25.5
Model coverage(%)97.9
Normalized DOPE score-0.815

Structure Models from Chopin
Model Number1
Profile1.20.140.10, 2.40.110.10
Click for model details
zscore39.07
Residue begin1
Residue end387
Model Number2
Profilea.29.3.1
Click for model details
zscore30.64
Residue begin228
Residue end380
Model Number3
Profilee.6.1.1
Click for model details
zscore18.15
Residue begin6
Residue end118
Model Number4
Profile2.40.110.10
Click for model details
zscore15.93
Residue begin111
Residue end240
Model Number5
Profilee.6.1.1
Click for model details
zscore13.36
Residue begin1
Residue end231
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3543cGene nameConfidence Score
Rv3540cltp20.995
Rv3540cltp20.995
Rv3541cRv3541c0.989
Rv3542cRv3542c0.986
Rv3542cRv3542c0.986
Rv3544cfadE280.985
Rv3544cfadE280.985
Rv1071cechA90.957
Rv1071cechA90.957
Rv3516echA190.937
Rv3550echA200.937
Rv0456cechA20.931
Rv2679echA150.931
Rv1935cechA130.93
Rv0675echA50.93
Rv0673echA40.928
Rv1141cechA110.924
Rv2831echA160.923
Rv3551Rv35510.921
Rv1142cechA100.92
Rv0222echA10.919
Rv0971cechA70.919
Rv0632cechA30.919
Rv3561fadD30.91
Rv3561fadD30.91
Rv0860fadB0.908
Rv0860fadB0.908
Rv3545ccyp1250.908
Rv0860fadB0.908
Rv3552Rv35520.905
Rv3774echA210.904
Rv2790cltp10.901
Rv1058fadD140.901
Rv1058fadD140.901
Rv2790cltp10.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.905785.55
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
adenosine monophosphatePubChem0.9347.221