Rv3544c

Tuberculist information
Gene namefadE28
Protein functionProbable acyl-CoA dehydrogenase FadE28
Functional category(tuberculist)lipid metabolism
Gene location(kb)3983.12
Molecular mass(da)35468.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 339
	  		  	1    MDFDPTAEQQAVADVVTSVLERDISWEALVCGGVTALPVPERLGGDGVGLFEVGALLTEV   60
			  	61   GRHGAVTPALATLGLGVVPLLELASAEQQDRFLAGVAKGGVLTAALNEPGAALPDRPATS  120
			  	121  FVGGRLSGTKVGVGYAEQADWMLVTADNAVVVVSPTADGVRMVRTPTSNGSDEYVMTMDG  180
			  	181  VAVADCDILADVAAHRVNQLALAVMGAYADGLVAGALRLTADYVANRKQFGKPLSTFQTV  240
			  	241  AAQLAEVYIASRTIDLVAKSVIWRLAEDLDAGDDLGVLGYWVTSQAPPAMQICHHLHGGM  300
			  	301  GMDVTYPMHRYYSTIKDLTRLLGGPSHRLELLGARCSLT

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 4 to 100  |  Coverage: 28% Acyl-CoA_dh_N Range: 190 to 337  |  Coverage: 43% Acyl-CoA_dh_1 Range: 1 to 339  |  Coverage: 99% 1 Range: 1 to 339  |  Coverage: 99% 1 Range: 192 to 337  |  Coverage: 42% 2 Range: 4 to 100  |  Coverage: 28% 3
Number of amino acids : 339
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027714-100
Acyl-CoA_dh_1PF00441190-337
Mtb Structural Proteome models
Model Number1
Model nameRv3544c
Template1UKW    APDBCREDO
Template coverage32_409
Template Identity(%)23.0
Model coverage(%)99.7
Normalized DOPE score-0.366

Structure Models from Chopin
Model Number1
Profilea.29.3.1, e.6.1.1 - 1.10.540.10, 1.20.140.10, 2.40.110.10
Click for model details
zscore37.82
Residue begin1
Residue end339
Model Number2
Profilea.29.3.1
Click for model details
zscore32.15
Residue begin192
Residue end337
Model Number3
Profile1.10.540.10
Click for model details
zscore14.17
Residue begin4
Residue end100
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3544cGene nameConfidence Score
Rv3543cfadE290.985
Rv3543cfadE290.985
Rv3543cfadE290.985
Rv3540cltp20.979
Rv3540cltp20.979
Rv3516echA190.963
Rv3542cRv3542c0.959
Rv3541cRv3541c0.959
Rv3542cRv3542c0.959
Rv1071cechA90.95
Rv1071cechA90.95
Rv3550echA200.95
Rv0456cechA20.93
Rv2679echA150.93
Rv1935cechA130.923
Rv0675echA50.923
Rv2831echA160.92
Rv1141cechA110.92
Rv0673echA40.92
Rv1142cechA100.917
Rv0971cechA70.917
Rv0632cechA30.916
Rv3545ccyp1250.916
Rv0222echA10.915
Rv3774echA210.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine monophosphatePubChem0.9347.221
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
flavin adenine dinucleotidePubChem0.9785.55
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073