Tuberculist information
Gene nameechA16
Protein functionProbable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3137.27
Molecular mass(da)26630.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 249
	  		  	1    MTDDILLIDTDERVRTLTLNRPQSRNALSAALRDRFFAALADAEADDDIDVVILTGADPV   60
			  	61   FCAGLDLKELAGQTALPDISPRWPAMTKPVIGAINGAAVTGGLELALYCDILIASEHARF  120
			  	121  ADTHARVGLLPTWGLSVRLPQKVGIGLARRMSLTGDYLSATDALRAGLVTEVVAHDQLLP  180
			  	181  TARRVAASIVGNNQNAVRALLASYHRIDESQTAAGLWLEACAAKQFRTSGDTIAANREAV  240
			  	241  LQRGRAQVR
			  			

Known structures in the PDB
PDB ID4JJT
Total residue count756
Number of chains3
MethodX-RAY
Resolution2.5
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF003787-239
Mtb Structural Proteome models
Model Number1
Model nameRv2831
Template1MJ3    APDBCREDO
Template coverage32_288
Template Identity(%)31.9
Model coverage(%)99.2
Normalized DOPE score-0.468

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore35.82
Residue begin1
Residue end249
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2831Gene nameConfidence Score
Rv0468fadB20.96
Rv0468fadB20.96
Rv1715fadB30.957
Rv1715fadB30.957
Rv0852fadD160.95
Rv1550fadD110.949
Rv1467cfadE150.936
Rv1467cfadE150.936
Rv1467cfadE150.936
Rv1467cfadE150.936
Rv1467cfadE150.936
Rv1679fadE160.933
Rv3562fadE310.933
Rv1934cfadE170.933
Rv1679fadE160.933
Rv1934cfadE170.933
Rv1679fadE160.933
Rv1934cfadE170.933
Rv0860fadB0.933
Rv3562fadE310.933
Rv0860fadB0.933
Rv3562fadE310.933
Rv0860fadB0.933
Rv3564fadE330.931
Rv3564fadE330.931
Rv1933cfadE180.931
Rv1933cfadE180.931
Rv0231fadE40.93
Rv3505fadE270.93
Rv0131cfadE10.93
Rv0271cfadE60.93
Rv0231fadE40.93
Rv3505fadE270.93
Rv0131cfadE10.93
Rv0271cfadE60.93
Rv0131cfadE10.93
Rv0271cfadE60.93
Rv3563fadE320.928
Rv3560cfadE300.928
Rv3563fadE320.928
Rv3560cfadE300.928
Rv3560cfadE300.928
Rv0154cfadE20.928
Rv0154cfadE20.928
Rv0154cfadE20.928
Rv3543cfadE290.923
Rv3543cfadE290.923
Rv3543cfadE290.923
Rv3504fadE260.92
Rv3544cfadE280.92
Rv3504fadE260.92
Rv3504fadE260.92
Rv3544cfadE280.92
Rv0244cfadE50.912
Rv0244cfadE50.912
Rv0244cfadE50.912
Rv2502caccD10.912
Rv0244cfadE50.912
Rv0244cfadE50.912
Rv3761cfadE360.905
Rv0400cfadE70.904
Rv0400cfadE70.904
Rv0400cfadE70.904
Rv3274cfadE250.902
Rv3274cfadE250.902
Rv3274cfadE250.902
Rv2724cfadE200.901
Rv2724cfadE200.901
Rv2724cfadE200.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.908835.608
methacrylyl-CoAPubChem0.901835.608
3-hydroxybutyryl-CoAPubChem0.901853.623
acryloyl-CoAPubChem0.901821.581
C05268PubChem0.9881.677
C11946PubChem0.9917.752
C0885PubChem0.9917.752
methylcrotonyl CoAPubChem0.9849.635
c0887PubChem0.9935.767
C16469PubChem0.9893.687
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
C05258PubChem0.91021.94
C05271PubChem0.9863.661
3-hydroxyadipyl-CoAPubChem0.9911.659
C05262PubChem0.9965.836
C11947PubChem0.9935.767
C05273PubChem0.9975.874
C05266PubChem0.9909.73
C14145PubChem0.9911.659
C03221PubChem0.9947.821
2MCPubChem0.9835.608
C01144PubChem0.9853.623
3-hydroxypropionyl-coenzyme APubChem0.9839.597
C16468PubChem0.9875.672
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C04405PubChem0.9867.65
C05275PubChem0.9919.768
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
C05260PubChem0.9993.889
3-hydroxypropionyl-CoAPubChem0.9839.597
trans-2-hexadecenoyl-CoAPubChem0.91003.93
3-methylcrotonyl-CoAPubChem0.9849.635
3-hydroxydecanoyl-CoAPubChem0.9937.783
C11945PubChem0.9917.752
C05276PubChem0.9891.714