Rv3761c

Tuberculist information
Gene namefadE36
Protein functionPossible acyl-CoA dehydrogenase FadE36
Functional category(tuberculist)lipid metabolism
Gene location(kb)4205.86
Molecular mass(da)38532.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 351
	  		  	1    VTSVDRLDGLDLGALDRYLRSLGIGRDGELRGELISGGRSNLTFRVYDDASSWLVRRPPL   60
			  	61   HGLTPSAHDMAREYRVVAALGDTPVPVARTISLCQDDSVLGAPFQVVEFVAGQVVRRRAE  120
			  	121  LEALGSRSVIEGCVDALIRVLVDLHSIDPKAVGLSDFGKPDGYLERQVRRWGSQWELVRL  180
			  	181  PDDHRDADISRLHLALQQAIPQQSRTSIVHGDYRIDNTILDTDDPCHVRAVVDWELSTLG  240
			  	241  DPLSDAALMCVYRDPALDLIVHAQAAWTSPLLPAADELADRYSLVSGQPLGHWEFYMALA  300
			  	301  YFKLAIIAAGIDYRRRMSEQAEGKDTAAESVPDVVAPLIARGLAEIAKKSG

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 31 to 294  |  Coverage: 74% APH Range: 11 to 302  |  Coverage: 82% 1 Range: 3 to 351  |  Coverage: 99% 1
Number of amino acids : 351
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
APHPF0163631-294
Mtb Structural Proteome models
Model Number1
Model nameRv3761c
Template1ND4    APDBCREDO
Template coverage11_263
Template Identity(%)17.8
Model coverage(%)82.9
Normalized DOPE score0.508

Structure Models from Chopin
Model Number1
Profiled.144.1.6
Click for model details
zscore17.91
Residue begin3
Residue end351
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3761cGene nameConfidence Score
Rv0154cfadE20.969
Rv0154cfadE20.969
Rv0154cfadE20.969
Rv0860fadB0.924
Rv0860fadB0.924
Rv0860fadB0.924
Rv0131cfadE10.919
Rv0131cfadE10.919
Rv0131cfadE10.919
Rv1142cechA100.914
Rv1141cechA110.912
Rv0222echA10.912
Rv1070cechA80.91
Rv3516echA190.908
Rv1472echA120.907
Rv2486echA140.906
Rv0905echA60.905
Rv2831echA160.905
Rv0675echA50.904
Rv3774echA210.904
Rv0971cechA70.903
Rv3039cechA170.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
c1137PubChem0.9875.672
C16468PubChem0.9875.672
5-methylhex-4-enoyl-CoAPubChem0.9877.688
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79