Rv3039c

Tuberculist information
Gene nameechA17
Protein functionProbable enoyl-CoA hydratase EchA17 (crotonase) (unsatured acyl-CoA hydratase) (enoyl hydrase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3399.42
Molecular mass(da)26505.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 254
	  		  	1    VPEFVNVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVVAAANELGRRDDVAAVILYGG   60
			  	61   HEIFSAGDDMPELRTLSAQEADTAARIRQQAVDAVAAIPKPTVAAITGYALGAGLTLALA  120
			  	121  ADWRVSGDNVKFGATEILAGLIPSGDGMARLTRAAGPSRAKELVFSGRFFDAEEALALGL  180
			  	181  IDDMVAPDDVYDAAAAWARRFLDGPPHALAAAKAGISDVYELAPAERIAAERRRYVEVFA  240
			  	241  AGQGGGSKGDRGGR

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 13 to 244  |  Coverage: 90% ECH Range: 13 to 244  |  Coverage: 90% 1 Range: 1 to 254  |  Coverage: 99% 1
Number of amino acids : 254
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF0037813-244
Mtb Structural Proteome models
Model Number1
Model nameRv3039c
Template1HZD    APDBCREDO
Template coverage84_321
Template Identity(%)34.1
Model coverage(%)90.6
Normalized DOPE score0.031

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore39.14
Residue begin1
Residue end254
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3039cGene nameConfidence Score
Rv1550fadD110.981
Rv1715fadB30.979
Rv1715fadB30.979
Rv0468fadB20.975
Rv0468fadB20.975
Rv0860fadB0.915
Rv2500cfadE190.915
Rv0860fadB0.915
Rv0860fadB0.915
Rv2500cfadE190.915
Rv2500cfadE190.915
Rv2502caccD10.91
Rv1467cfadE150.906
Rv1467cfadE150.906
Rv0244cfadE50.906
Rv0244cfadE50.906
Rv0244cfadE50.906
Rv1467cfadE150.906
Rv0244cfadE50.906
Rv1467cfadE150.906
Rv0244cfadE50.906
Rv1467cfadE150.906
Rv3274cfadE250.904
Rv3274cfadE250.904
Rv0672fadE80.904
Rv3274cfadE250.904
Rv0672fadE80.904
Rv0400cfadE70.903
Rv0400cfadE70.903
Rv2724cfadE200.903
Rv2724cfadE200.903
Rv2724cfadE200.903
Rv0400cfadE70.903
Rv3761cfadE360.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.908835.608
3-hydroxybutyryl-CoAPubChem0.904853.623
methacrylyl-CoAPubChem0.902835.608
acryloyl-CoAPubChem0.902821.581
3-hydroxypropionyl-CoAPubChem0.901839.597
3-hydroxypropionyl-coenzyme APubChem0.9839.597
C0885PubChem0.9917.752
trans-2-enoyl-CoAsPubChem0.9821.581
C16468PubChem0.9875.672
NSC112207PubChem0.9785.55
c0887PubChem0.9935.767
1,5-dihydro-FADPubChem0.9787.566
C05258PubChem0.91021.94
c1138PubChem0.9893.687
C05260PubChem0.9993.889
CHEBI:15489PubChem0.9837.581
H(+)PubChem0.92.01588
C05271PubChem0.9863.661
2MCPubChem0.9835.608
C11947PubChem0.9935.767
3-hydroxydecanoyl-CoAPubChem0.9937.783
3-hydroxyadipyl-CoAPubChem0.9911.659
C05273PubChem0.9975.874
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C14145PubChem0.9911.659
C05268PubChem0.9881.677
FADH2PubChem0.9787.566
C03221PubChem0.9947.821
methylcrotonyl CoAPubChem0.9849.635
C11946PubChem0.9917.752
C05989PubChem0.9837.581
flavin adenine dinucleotidePubChem0.9785.55
C04405PubChem0.9867.65
c1137PubChem0.9875.672
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
C16469PubChem0.9893.687
AR-1A9122PubChem0.9787.566
C05275PubChem0.9919.768
deuteriumPubChem0.92.01588
C05262PubChem0.9965.836
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
trans-2-hexadecenoyl-CoAPubChem0.91003.93
NAD+PubChem0.9663.425
C11945PubChem0.9917.752
C05266PubChem0.9909.73
3-methylcrotonyl-CoAPubChem0.9849.635
C01144PubChem0.9853.623
C05276PubChem0.9891.714
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576