Rv2500c

Tuberculist information
Gene namefadE19
Protein functionPossible acyl-CoA dehydrogenase FadE19 (MMGC)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2813.73
Molecular mass(da)41916.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 394
	  		  	1    MTTTTTTISGGILPKEYQDLRDTVADFARTVVAPVSAKHDAEHSFPYEIVAKMGEMGLFG   60
			  	61   LPFPEEYGGMGGDYFALSLVLEELGKVDQSVAITLEAAVGLGAMPIYRFGTEEQKQKWLP  120
			  	121  DLTSGRALAGFGLTEPGAGSDAGSTRTTARLEGDEWIINGSKQFITNSGTDITSLVTVTA  180
			  	181  VTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGWNASDTHPLTFADARVPRENLLG  240
			  	241  ARGSGYANFLSILDEGRIAIAALATGAAQGCVDESVKYANQRQSFGQPIGAYQAIGFKIA  300
			  	301  RMEARAHVARTAYYDAAAKMLAGKPFKKEAAIAKMISSEAAMDNSRDATQIHGGYGFMNE  360
			  	361  YPVARHYRDSKVLEIGEGTTEVQLMLIARSLGLQ

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 14 to 126  |  Coverage: 28% Acyl-CoA_dh_N Range: 130 to 183  |  Coverage: 13% Acyl-CoA_dh_M Range: 243 to 392  |  Coverage: 37% Acyl-CoA_dh_1 Range: 13 to 391  |  Coverage: 95% 1 Range: 8 to 394  |  Coverage: 97% 1 Range: 241 to 394  |  Coverage: 38% 2 Range: 1 to 246  |  Coverage: 62% 3 Range: 14 to 126  |  Coverage: 28% 4 Range: 1 to 385  |  Coverage: 97% 5
Number of amino acids : 394
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF0277114-126
Acyl-CoA_dh_MPF02770130-183
Acyl-CoA_dh_1PF00441243-392
Mtb Structural Proteome models
Model Number1
Model nameRv2500c
Template1JQI    APDBCREDO
Template coverage10_382
Template Identity(%)44.5
Model coverage(%)95.9
Normalized DOPE score-1.01

Structure Models from Chopin
Model Number1
Profile1.20.140.10, 2.40.110.10
Click for model details
zscore65.94
Residue begin8
Residue end394
Model Number2
Profilea.29.3.1
Click for model details
zscore35.6
Residue begin241
Residue end394
Model Number3
Profilee.6.1.1
Click for model details
zscore19.9
Residue begin1
Residue end246
Model Number4
Profile1.10.540.10
Click for model details
zscore18.64
Residue begin14
Residue end126
Model Number5
Profilee.6.1.2
Click for model details
zscore9.28
Residue begin1
Residue end385
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2500cGene nameConfidence Score
Rv3774echA210.976
Rv0860fadB0.94
Rv0860fadB0.94
Rv0860fadB0.94
Rv3039cechA170.915
Rv3561fadD30.911
Rv3561fadD30.911
Rv0166fadD50.91
Rv0166fadD50.91
Rv3516echA190.907
Rv1058fadD140.905
Rv1058fadD140.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.958785.55
butyryl-CoAPubChem0.927837.624
2-methylbutyryl-CoAPubChem0.916851.651
hexanoyl-CoAPubChem0.915865.677
coenzyme APubChem0.912767.534
crotonyl-CoAPubChem0.909835.608
formatePubChem0.90545.0174
adenosine monophosphatePubChem0.902347.221
crotonyl-coenzyme APubChem0.901835.608
C05271PubChem0.9863.661
CHEBI:15477PubChem0.9851.651
Co-APubChem0.9767.534
deuteriumPubChem0.92.01588
FADH2PubChem0.9787.566
adenosine triphosphatePubChem0.9507.181
pyrophosphatePubChem0.9177.975
protiumPubChem0.92.01576
NSC112207PubChem0.9785.55
Tiglyl-coenzyme APubChem0.9849.635
H(+)PubChem0.92.01588
trans-2-hexenoyl-coenzyme APubChem0.9863.661
1,5-dihydro-FADPubChem0.9787.566
butyryl coenzyme APubChem0.9837.624
hydroxyl radicalsPubChem0.917.0073
hexanoyl-coenzyme APubChem0.9865.677
methylcrotonyl CoAPubChem0.9849.635
AR-1A9122PubChem0.9787.566