Rv1467c

Tuberculist information
Gene namefadE15
Protein functionProbable acyl-CoA dehydrogenase FadE15
Functional category(tuberculist)lipid metabolism
Gene location(kb)1653.67
Molecular mass(da)65905.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 609
	  		  	1    LGHYIANVRDLEFNLLEVLDIGAVLGTGRYSDLDVDTVRTILAEAARLAEGPIAESFGYA   60
			  	61   DRNPPVFDPNTHSISVPDELAKTVQAIKEAGWWRLGLAEEIGGMPAPPPLAWAVNEMIYC  120
			  	121  ANPSACFFNLGPVLAQSLYIEGNDEQRRWAAEGVQRGWQATMVLTEPDAGSDVGAGRTKA  180
			  	181  FEQPDGTWHIEGVKRFISGGDVGNTAENIFHLVLARPEGAGPGTKGLSLFYVPNYLFDPD  240
			  	241  TFELGARNGVYVTGLEHKMGLKSSPTCELTFGGADVPAVGYLVGGVHNGIAQMFTVIEHA  300
			  	301  RMTIGVKSAGTLSTGYLNALAFAKERVQGADLTQMTDKTAPRVTIMHHPDVRRSLMTQKA  360
			  	361  YAEGLRALYLYAAAHQDDAVAQRVSGADHDMAHRVDDLLLPIVKGVGSERAYEILTESLQ  420
			  	421  TLGGSGFLVDYPLEQYIRDAKIDSLYEGTTAIQALDFFFRKIVRDHGKALQFVLAQVTHT  480
			  	481  VENIDPSLKPQAELLRTALDDITAMTGALTGYLMSAAQHSSDIYKVGLGSVRYLLAVGDL  540
			  	541  LIGWRLLVLAGVAHAALADGPSQNDEAFYRGKIAVAAFFAKNMLPKLTGVRSVIENIDDD  600
			  	601  IMRVPEDAF

Known structures in the PDB
No Known structures
1 61 121 181 241 301 361 421 481 541 601 Range: 2 to 34  |  Coverage: 5% AcylCoA_DH_N Range: 36 to 157  |  Coverage: 19% Acyl-CoA_dh_N Range: 161 to 219  |  Coverage: 9% Acyl-CoA_dh_M Range: 287 to 457  |  Coverage: 27% Acyl-CoA_dh_1 Range: 472 to 606  |  Coverage: 22% Acyl-CoA_dh_C Range: 20 to 607  |  Coverage: 96% 1 Range: 27 to 468  |  Coverage: 72% 1 Range: 285 to 475  |  Coverage: 31% 2 Range: 158 to 299  |  Coverage: 23% 3 Range: 11 to 289  |  Coverage: 45% 4 Range: 16 to 609  |  Coverage: 97% 5
Number of amino acids : 609
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AcylCoA_DH_NPF124182-34
Acyl-CoA_dh_NPF0277136-157
Acyl-CoA_dh_MPF02770161-219
Acyl-CoA_dh_1PF00441287-457
Acyl-CoA_dh_CPF12806472-606
Mtb Structural Proteome models
Model Number1
Model nameRv1467c
Template1W07    APDBCREDO
Template coverage3_588
Template Identity(%)15.1
Model coverage(%)96.4
Normalized DOPE score0.563

Structure Models from Chopin
Model Number1
Profile1.10.540.10, 2.40.110.10
Click for model details
zscore36.94
Residue begin27
Residue end468
Model Number2
Profilea.29.3.1
Click for model details
zscore20.76
Residue begin285
Residue end475
Model Number3
Profile2.40.110.10
Click for model details
zscore14.92
Residue begin158
Residue end299
Model Number4
Profilee.6.1.1
Click for model details
zscore14.49
Residue begin11
Residue end289
Model Number5
Profilea.29.3.2, e.6.1.2 - 1.20.140.10, 2.40.110.10
Click for model details
zscore10.88
Residue begin16
Residue end609
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1467cGene nameConfidence Score
Rv0860fadB0.965
Rv0860fadB0.965
Rv0860fadB0.965
Rv1071cechA90.956
Rv1071cechA90.956
Rv0456cechA20.937
Rv0675echA50.936
Rv2831echA160.936
Rv2679echA150.934
Rv1935cechA130.931
Rv1141cechA110.931
Rv0673echA40.93
Rv3550echA200.93
Rv0222echA10.93
Rv1070cechA80.927
Rv1142cechA100.926
Rv3516echA190.926
Rv0971cechA70.926
Rv1472echA120.925
Rv0632cechA30.92
Rv3774echA210.919
Rv0905echA60.909
Rv1058fadD140.907
Rv1058fadD140.907
Rv3039cechA170.906
Rv0166fadD50.905
Rv0166fadD50.905
Rv2486echA140.903
Rv3373echA180.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine monophosphatePubChem0.9347.221
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
flavin adenine dinucleotidePubChem0.9785.55
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073