Rv3373

Tuberculist information
Gene nameechA18
Protein functionProbable enoyl-CoA hydratase EchA18 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3787.73
Molecular mass(da)22662.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 213
	  		  	1    MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVALITLSHPQAQ   60
			  	61   NALNLASWRRLKRLLDDLAGESGLRAVVLRGAGDKAFAAGADIKEFPNTRMSAADAAEYN  120
			  	121  ESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCIATDDARFGIPLGKLGVTTGF  180
			  	181  TEADTVARLIGPAALKYLLFSGELIGIEEAARW

Known structures in the PDB
No Known structures
1 22 43 64 85 106 127 148 169 190 211 Range: 42 to 213  |  Coverage: 80% ECH Range: 41 to 210  |  Coverage: 79% 1 Range: 1 to 213  |  Coverage: 99% 1
Number of amino acids : 213
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF0037842-213
Mtb Structural Proteome models
Model Number1
Model nameRv3373
Template1UIY    APDBCREDO
Template coverage2_169
Template Identity(%)36.9
Model coverage(%)79.3
Normalized DOPE score-0.346

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore29.06
Residue begin1
Residue end213
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3373Gene nameConfidence Score
Rv3375amiD0.976
Rv0468fadB20.956
Rv0468fadB20.956
Rv3374echA18.10.93
Rv3376Rv33760.927
Rv1715fadB30.926
Rv1715fadB30.926
Rv0860fadB0.909
Rv0860fadB0.909
Rv0860fadB0.909
Rv2502caccD10.903
Rv0244cfadE50.902
Rv0672fadE80.902
Rv0244cfadE50.902
Rv0672fadE80.902
Rv0244cfadE50.902
Rv0244cfadE50.902
Rv0244cfadE50.902
Rv1467cfadE150.901
Rv1467cfadE150.901
Rv1467cfadE150.901
Rv1467cfadE150.901
Rv1467cfadE150.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
3-hydroxybutyryl-CoAPubChem0.904853.623
coenzyme APubChem0.903767.534
crotonyl-CoAPubChem0.903835.608
2-methylacetoacetyl-coenzyme APubChem0.9865.634
3-hydroxypropionyl-coenzyme APubChem0.9839.597
flavin adenine dinucleotidePubChem0.9785.55
C11945PubChem0.9917.752
C0885PubChem0.9917.752
trans-2-enoyl-CoAsPubChem0.9821.581
2-methylacetoacetyl-CoAPubChem0.9865.634
C01144PubChem0.9853.623
c0887PubChem0.9935.767
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
NSC112207PubChem0.9785.55
c1138PubChem0.9893.687
C05260PubChem0.9993.889
3-hydroxyadipyl-CoAPubChem0.9911.659
methacrylyl-CoAPubChem0.9835.608
C05271PubChem0.9863.661
2MCPubChem0.9835.608
CHEBI:15477PubChem0.9851.651
H(+)PubChem0.92.01588
3-hydroxydecanoyl-CoAPubChem0.9937.783
C05258PubChem0.91021.94
C05273PubChem0.9975.874
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C16469PubChem0.9893.687
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05268PubChem0.9881.677
C11947PubChem0.9935.767
C03221PubChem0.9947.821
methylcrotonyl CoAPubChem0.9849.635
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
acryloyl-CoAPubChem0.9821.581
alpha-methylbutyryl-CoAPubChem0.9851.651
C05989PubChem0.9837.581
1,5-dihydro-FADPubChem0.9787.566
C14145PubChem0.9911.659
c1137PubChem0.9875.672
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methylbutyryl-CoAPubChem0.9851.651
FADH2PubChem0.9787.566
C05275PubChem0.9919.768
isobutyryl-CoAPubChem0.9837.624
C11946PubChem0.9917.752
AR-1A9122PubChem0.9787.566
C05262PubChem0.9965.836
3-methylcrotonyl-CoAPubChem0.9849.635
C04405PubChem0.9867.65
trans-2-hexadecenoyl-CoAPubChem0.91003.93
NAD+PubChem0.9663.425
C16468PubChem0.9875.672
AR-1H5729PubChem0.9835.608
C05266PubChem0.9909.73
3-hydroxypropionyl-CoAPubChem0.9839.597
C05276PubChem0.9891.714
hydroxyl radicalsPubChem0.917.0073
CHEBI:15489PubChem0.9837.581
Co-APubChem0.9767.534