Rv3375

Tuberculist information
Gene nameamiD
Protein functionProbable amidase AmiD (acylamidase) (acylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3788.62
Molecular mass(da)50645.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 475
	  		  	1    MTDADSAVPPRLDEDAISKLELTEVADLIRTRQLTSAEVTESTLRRIERLDPQLKSYAFV   60
			  	61   MPETALAAARAADADIARGHYEGVLHGVPIGVKDLCYTVDAPTAAGTTIFRDFRPAYDAT  120
			  	121  VVARLRAAGAVIIGKLAMTEGAYLGYHPSLPTPVNPWDPTAWAGVSSSGCGVATAAGLCF  180
			  	181  GSIGSDTGGSIRFPTSMCGVTGIKPTWGRVSRHGVVELAASYDHVGPITRSAHDAAVLLS  240
			  	241  VIAGSDIHDPSCSAEPVPDYAADLALTRIPRVGVDWSQTTSFDEDTTAMLADVVKTLDDI  300
			  	301  GWPVIDVKLPALAPMVAAFGKMRAVETAIAHADTYPARADEYGPIMRAMIDAGHRLAAVE  360
			  	361  YQTLTERRLEFTRSLRRVFHDVDILLMPSAGIASPTLETMRGLGQDPELTARLAMPTAPF  420
			  	421  NVSGNPAICLPAGTTARGTPLGVQFIGREFDEHLLVRAGHAFQQVTGYHRRRPPV

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 38 to 456  |  Coverage: 88% Amidase Range: 16 to 475  |  Coverage: 96% 1 Range: 1 to 475  |  Coverage: 99% 1
Number of amino acids : 475
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AmidasePF0142538-456
Mtb Structural Proteome models
Model Number1
Model nameRv3375
Template2F2A    APDBCREDO
Template coverage2_485
Template Identity(%)30.7
Model coverage(%)96.6
Normalized DOPE score-0.572

Structure Models from Chopin
Model Number1
Profilec.117.1.1 - 3.90.1300.10
Click for model details
zscore57.5
Residue begin1
Residue end475
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3375Gene nameConfidence Score
Rv3373echA180.976
Rv3374echA18.10.976
Rv3009cgatB0.957
Rv3009cgatB0.957
Rv3376Rv33760.929
Rv1908ckatG0.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
auxinPubChem0.905174.176
benzoic acidPubChem0.901121.113
benzeneacetamidePubChem0.9135.163