Rv3374

Tuberculist information
Gene nameechA18.1
Protein functionProbable enoyl-CoA hydratase (fragment) EchA18.1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3788.37
Molecular mass(da)8597.84
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 82
	  		  	1    LVQKVVAPQDLAAATAKLVGQVCRQSAVTMRAAKVVANMHGRALTGADTDALIRFGVEAY   60
			  	61   EGADLREGVAAFSQGRPPKFDD

Known structures in the PDB
No Known structures
1 9 17 25 33 41 49 57 65 73 81 Range: 1 to 82  |  Coverage: 98% ClpP/crotonase Range: 1 to 82  |  Coverage: 98% 1 Range: 24 to 82  |  Coverage: 70% 1
Number of amino acids : 82
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ClpP/crotonasec.14.11-82
Mtb Structural Proteome models
Model Number1
Model nameRv3374
Template1MJ3    APDBCREDO
Template coverage208_289
Template Identity(%)19.5
Model coverage(%)97.6
Normalized DOPE score0.763

Structure Models from Chopin
Model Number1
Profile1.10.12.10
Click for model details
zscore14.13
Residue begin24
Residue end82
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3374Gene nameConfidence Score
Rv3375amiD0.976
Rv3373echA180.93
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
c1138PubChem0.9893.687
C05260PubChem0.9993.889
3-hydroxyadipyl-CoAPubChem0.9911.659
methacrylyl-CoAPubChem0.9835.608
H(+)PubChem0.92.01588
C05271PubChem0.9863.661
2MCPubChem0.9835.608
CHEBI:15477PubChem0.9851.651
3-hydroxydecanoyl-CoAPubChem0.9937.783
coenzyme APubChem0.9767.534
C05258PubChem0.91021.94
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05273PubChem0.9975.874
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C16469PubChem0.9893.687
C05268PubChem0.9881.677
crotonyl-CoAPubChem0.9835.608
C11947PubChem0.9935.767
C03221PubChem0.9947.821
methylcrotonyl CoAPubChem0.9849.635
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
acryloyl-CoAPubChem0.9821.581
alpha-methylbutyryl-CoAPubChem0.9851.651
C05989PubChem0.9837.581
1,5-dihydro-FADPubChem0.9787.566
C14145PubChem0.9911.659
c1137PubChem0.9875.672
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methylbutyryl-CoAPubChem0.9851.651
FADH2PubChem0.9787.566
AR-1A9122PubChem0.9787.566
C05275PubChem0.9919.768
isobutyryl-CoAPubChem0.9837.624
C11946PubChem0.9917.752
C05262PubChem0.9965.836
3-methylcrotonyl-CoAPubChem0.9849.635
C04405PubChem0.9867.65
AR-1H5729PubChem0.9835.608
trans-2-hexadecenoyl-CoAPubChem0.91003.93
NAD+PubChem0.9663.425
C16468PubChem0.9875.672
C05266PubChem0.9909.73
3-hydroxybutyryl-CoAPubChem0.9853.623
3-hydroxypropionyl-CoAPubChem0.9839.597
Co-APubChem0.9767.534
C05276PubChem0.9891.714
hydroxyl radicalsPubChem0.917.0073
CHEBI:15489PubChem0.9837.581
2-methylacetoacetyl-coenzyme APubChem0.9865.634
3-hydroxypropionyl-coenzyme APubChem0.9839.597
flavin adenine dinucleotidePubChem0.9785.55
C11945PubChem0.9917.752
C0885PubChem0.9917.752
trans-2-enoyl-CoAsPubChem0.9821.581
2-methylacetoacetyl-CoAPubChem0.9865.634
C01144PubChem0.9853.623
NSC112207PubChem0.9785.55
c0887PubChem0.9935.767
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576