Rv1715

Tuberculist information
Gene namefadB3
Protein functionProbable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1942.66
Molecular mass(da)31506.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 304
	  		  	1    MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHAAAVEAARVAGAGRGS   60
			  	61   VAAAADLAAAIPDADLVIEAVVENLAVKQELFERLATLAPDAVLATNTSVLPIGAVTERV  120
			  	121  EDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVRVGRDVPGFIG  180
			  	181  NRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLGPLENADYIGLDLTLAIHDA  240
			  	241  VIPSLNHDPHPSPLLRELVAAGQLGARTGHGFLDWPAGAREATTARLAQHIAAQLQANEK  300
			  	301  GRGT

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 9 to 175  |  Coverage: 54% 3HCDH_N Range: 177 to 275  |  Coverage: 32% 3HCDH Range: 7 to 276  |  Coverage: 88% 1 Range: 4 to 276  |  Coverage: 89% 1 Range: 172 to 299  |  Coverage: 41% 2 Range: 1 to 106  |  Coverage: 34% 3 Range: 9 to 175  |  Coverage: 54% 4
Number of amino acids : 304
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
3HCDH_NPF027379-175
3HCDHPF00725177-275
Mtb Structural Proteome models
Model Number1
Model nameRv1715
Template3HDH    APDBCREDO
Template coverage15_302
Template Identity(%)35.6
Model coverage(%)88.5
Normalized DOPE score-0.346

Structure Models from Chopin
Model Number1
Profilea.100.1.3, c.2.1.6 - 1.10.1040.10, 3.40.50.720
Click for model details
zscore42.67
Residue begin4
Residue end276
Model Number2
Profilea.100.1.3
Click for model details
zscore18.67
Residue begin172
Residue end299
Model Number3
Profilec.5.1.1
Click for model details
zscore8.11
Residue begin1
Residue end106
Model Number4
Profilec.2.1.6
Click for model details
zscore8.05
Residue begin9
Residue end175
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1715Gene nameConfidence Score
Rv1472echA120.986
Rv3039cechA170.979
Rv1070cechA80.979
Rv1142cechA100.971
Rv1323fadA40.962
Rv1323fadA40.962
Rv0675echA50.959
Rv2831echA160.957
Rv1074cfadA30.956
Rv1074cfadA30.956
Rv0971cechA70.955
Rv3556cfadA60.954
Rv3556cfadA60.954
Rv0859fadA0.952
Rv0859fadA0.952
Rv1071cechA90.952
Rv1071cechA90.952
Rv0905echA60.949
Rv3546fadA50.948
Rv3546fadA50.948
Rv3550echA200.946
Rv0673echA40.944
Rv2503cscoB0.942
Rv2504cscoA0.94
Rv3774echA210.939
Rv1141cechA110.936
Rv0222echA10.935
Rv0632cechA30.935
Rv0860fadB0.933
Rv0860fadB0.933
Rv0860fadB0.933
Rv1716Rv17160.932
Rv1717Rv17170.929
Rv3373echA180.926
Rv3516echA190.925
Rv0914cRv0914c0.919
Rv0914cRv0914c0.919
Rv0243fadA20.917
Rv0243fadA20.917
Rv2679echA150.916
Rv2486echA140.916
Rv1718Rv17180.906
Rv3523ltp30.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.942851.607
3-hydroxybutyryl-CoAPubChem0.924853.623
NADP(H)PubChem0.909745.421
deuteriumPubChem0.92.01588
C01144PubChem0.9853.623
[(2S,3S,4R,5S)-5-(6-aminopurin-9-yl)-2-[[[[4-[[3-[2-(1,3-dioxobutylthio)ethylamino]-3-oxopropyl]aminPubChem0.9847.576
NADPPubChem0.9744.413
H(+)PubChem0.92.01588
protiumPubChem0.92.01576