Rv3523

Tuberculist information
Gene nameltp3
Protein functionProbable lipid carrier protein or keto acyl-CoA thiolase Ltp3
Functional category(tuberculist)lipid metabolism
Gene location(kb)3959.53
Molecular mass(da)41421.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 394
	  		  	1    MAGKLAAVLGTGQTKYVAKRQDVSMNGLVREAIDRALADSGSTFDDIDAVVVGKAPDFFE   60
			  	61   GVMMPELFMADAMGATGKPLIRVHTAGSVGGSTGVVAASLVQSGKYRRVLALAWEKQSES  120
			  	121  NAMWALSIPVPFTKPVGAGAGGYFAPHVRAYIRRSGAPAHIGAMVAVKDRLNGSRNPLAH  180
			  	181  LQQPDITLEKVMASQMLWDPIRFDETCPSSDGACAVVVGDEEIADARLAQGHPVAWIHGT  240
			  	241  ALRTEPLAFAGRDQVNPQAGRDAAAALWKAAGITSPIDEIDAAEIYVPFSWFEPMWLENL  300
			  	301  GFAREGEGWKLTEAGETAIGGRLPVNPSGGVLSANPIGASGLIRFAEAAIQVMGKAEARQ  360
			  	361  VPGARKALGHAYGGGSQYFSMWVVGCEKPKQAAA

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 259 to 382  |  Coverage: 31% Thiolase_C Range: 3 to 387  |  Coverage: 97% 1 Range: 1 to 392  |  Coverage: 99% 1
Number of amino acids : 394
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_CPF02803259-382
Mtb Structural Proteome models
Model Number1
Model nameRv3523
Template2C7Y    APDBCREDO
Template coverage49_440
Template Identity(%)15.3
Model coverage(%)97.5
Normalized DOPE score0.431

Structure Models from Chopin
Model Number1
Profilec.95.1.1
Click for model details
zscore5.48
Residue begin1
Residue end392
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3523Gene nameConfidence Score
Rv3521Rv35210.952
Rv3522ltp40.926
Rv2790cltp10.924
Rv2790cltp10.924
Rv2504cscoA0.922
Rv1131prpC0.921
Rv0896gltA20.92
Rv0468fadB20.919
Rv0468fadB20.919
Rv2503cscoB0.91
Rv0889ccitA0.906
Rv3667acs0.906
Rv3667acs0.906
Rv1715fadB30.905
Rv1715fadB30.905
Rv0975cfadE130.902
Rv0975cfadE130.902
Rv0975cfadE130.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.903851.607
acetyl-CoAPubChem0.9809.571
3-ketohexanoyl-CoAPubChem0.9879.661
butyryl-CoAPubChem0.9837.624