Rv3667

Tuberculist information
Gene nameacs
Protein functionAcetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)4107.79
Molecular mass(da)71443.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 651
	  		  	1    VSESTPEVSSSYPPPAHFAEHANARAELYREAEEDRLAFWAKQANRLSWTTPFTEVLDWS   60
			  	61   GAPFAKWFVGGELNVAYNCVDRHVEAGHGDRVAIHWEGEPVGDRRTLTYSDLLAEVSKAA  120
			  	121  NALTDLGLVAGDRVAIYLPLIPEAVIAMLACARLGIMHSVVFGGFTAAALQARIVDAQAK  180
			  	181  LLITADGQFRRGKPSPLKAAADEALAAIPDCSVEHVLVVRRTGIEMAWSEGRDLWWHHVV  240
			  	241  GSASPAHTPEPFDSEHPLFLLYTSGTTGKPKGIMHTSGGYLTQCCYTMRTIFDVKPDSDV  300
			  	301  FWCTADIGWVTGHTYGVYGPLCNGVTEVLYEGTPDTPDRHRHFQIIEKYGVTIYYTAPTL  360
			  	361  IRMFMKWGREIPDSHDLSSLRLLGSVGEPINPEAWRWYRDVIGGGRTPLVDTWWQTETGS  420
			  	421  AMISPLPGIAAAKPGSAMTPLPGISAKIVDDHGDPLPPHTEGAQHVTGYLVLDQPWPSML  480
			  	481  RGIWGDPARYWHSYWSKFSDKGYYFAGDGARIDPDGAIWVLGRIDDVMNVSGHRISTAEV  540
			  	541  ESALVAHSGVAEAAVVGVTDETTTQAICAFVVLRANYAPHDRTAEELRTEVARVISPIAR  600
			  	601  PRDVHVVPELPKTRSGKIMRRLLRDVAENRELGDTSTLLDPTVFDAIRAAK

Known structures in the PDB
No Known structures
1 66 131 196 261 326 391 456 521 586 651 Range: 80 to 531  |  Coverage: 69% AMP-binding Range: 539 to 617  |  Coverage: 11% AMP-binding_C Range: 11 to 651  |  Coverage: 98% 1 Range: 10 to 645  |  Coverage: 97% 1 Range: 437 to 522  |  Coverage: 13% 2
Number of amino acids : 651
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AMP-bindingPF0050180-531
AMP-binding_CPF13193539-617
Mtb Structural Proteome models
Model Number1
Model nameRv3667
Template1PG4    APDBCREDO
Template coverage6_645
Template Identity(%)47.8
Model coverage(%)98.3
Normalized DOPE score-1.116

Structure Models from Chopin
Model Number1
Profilee.23.1.1
Click for model details
zscore57.87
Residue begin10
Residue end645
Model Number2
Profile2.30.38.10
Click for model details
zscore14.58
Residue begin437
Residue end522
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3667Gene nameConfidence Score
Rv0409ackA0.993
Rv0408pta0.992
Rv0408pta0.992
Rv0408pta0.992
Rv0458Rv04580.961
Rv1323fadA40.959
Rv0753cmmsA0.959
Rv1323fadA40.959
Rv2495cbkdC0.957
Rv3546fadA50.957
Rv2495cbkdC0.957
Rv3546fadA50.957
Rv2495cbkdC0.957
Rv1074cfadA30.956
Rv1074cfadA30.956
Rv3535chsaG0.954
Rv1837cglcB0.954
Rv2455cRv2455c0.954
Rv3535chsaG0.954
Rv2455cRv2455c0.954
Rv3556cfadA60.953
Rv3556cfadA60.953
Rv2858caldC0.95
Rv0859fadA0.949
Rv0859fadA0.949
Rv0147Rv01470.948
Rv0768aldA0.944
Rv3280accD50.936
Rv3710leuA0.936
Rv3710leuA0.936
Rv0904caccD30.934
Rv2967cpca0.933
Rv2967cpca0.933
Rv2967cpca0.933
Rv2967cpca0.933
Rv2967cpca0.933
Rv2967cpca0.933
Rv2496cbkdB0.932
Rv2496cbkdB0.932
Rv0973caccA20.93
Rv0973caccA20.93
Rv0973caccA20.93
Rv0973caccA20.93
Rv0243fadA20.929
Rv0243fadA20.929
Rv2922AacyP0.925
Rv0975cfadE130.924
Rv0975cfadE130.924
Rv0975cfadE130.924
Rv0914cRv0914c0.922
Rv0914cRv0914c0.922
Rv2497cbkdA0.922
Rv1617pykA0.92
Rv1617pykA0.92
Rv0467icl10.918
Rv0154cfadE20.908
Rv0154cfadE20.908
Rv0154cfadE20.908
Rv0231fadE40.907
Rv0231fadE40.907
Rv3523ltp30.906
Rv3140fadE230.904
Rv3140fadE230.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetatePubChem0.99259.044
acetyl-CoAPubChem0.987809.571
coenzyme APubChem0.982767.534
Co-APubChem0.975767.534
adenosine monophosphatePubChem0.962347.221
acetyl adenylatePubChem0.959389.258
propionyl-CoAPubChem0.956823.597
AcCoAPubChem0.95809.571
acetyl phosphatePubChem0.947140.032
phosphatePubChem0.92196.9872
pyrophosphatePubChem0.913177.975
adenosine triphosphatePubChem0.911507.181
carbon dioxidePubChem0.9144.0095
acetyl coenzyme-APubChem0.9809.571
H(+)PubChem0.92.01588
pyruvic acidPubChem0.988.0621
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
adenosine diphosphatePubChem0.9427.201
Adenosine 5'-propyl phosphatePubChem0.833389.301
magnesiumPubChem0.82724.305
adenosine-5'-propylphosphatePubChem0.815389.301
and CoAPubChem0.7311127.94
ethanolPubChem0.72446.0684