Rv0458

Tuberculist information
Gene nameRv0458
Protein functionProbable aldehyde dehydrogenase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)549.675
Molecular mass(da)54574.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 507
	  		  	1    MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVTGQPFCEVPRSDAADID   60
			  	61   KALDAAHAAAPGWGKTAPAERAAILNMIADRIDKNAAALAVAEVWDNGKPVREALAADIP  120
			  	121  LAVDHFRYFAAAIRAQEGALSQIDEDTVAYHFHEPLGVVGQIIPWNFPILMAAWKLAPAL  180
			  	181  AAGNTAVLKPAEQTPASVLYLMSLIGDLLPPGVVNVVNGFGAEAGKPLASSDRIAKVAFT  240
			  	241  GETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTMFALNQGE  300
			  	301  VCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPLDTETMLGSQASNDQLEKVLSYIEIG  360
			  	361  KQEGAVIIAGGERAELGGDLSGGYYMQPTIFTGTNNMRIFKEEIFGPVVAVTSFTDYDDA  420
			  	421  IGIANDTLYGLGAGVWSRDGNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGRE  480
			  	481  GHQMMLQHYQHTKNLLVSYSDKALGFF

Known structures in the PDB
No Known structures
1 51 101 151 201 251 301 351 401 451 501 Range: 28 to 495  |  Coverage: 92% Aldedh Range: 10 to 502  |  Coverage: 97% 1 Range: 1 to 507  |  Coverage: 99% 1 Range: 263 to 478  |  Coverage: 42% 2
Number of amino acids : 507
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AldedhPF0017128-495
Mtb Structural Proteome models
Model Number1
Model nameRv0458
Template1BXS    APDBCREDO
Template coverage9_498
Template Identity(%)41.4
Model coverage(%)97.0
Normalized DOPE score-0.446

Structure Models from Chopin
Model Number1
Profilec.82.1.1
Click for model details
zscore63.4
Residue begin1
Residue end507
Model Number2
Profile3.40.309.10
Click for model details
zscore44.36
Residue begin263
Residue end478
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0458Gene nameConfidence Score
Rv0459Rv04590.984
Rv3535chsaG0.977
Rv3535chsaG0.977
Rv0409ackA0.962
Rv3667acs0.961
Rv3667acs0.961
Rv3432cgadB0.936
Rv0751cmmsB0.936
Rv0751cmmsB0.936
Rv2589gabT0.935
Rv0853cpdc0.923
Rv0853cpdc0.923
Rv0853cpdc0.923
Rv1862adhA0.918
Rv1862adhA0.918
Rv3601cpanD0.917
Rv0761cadhB0.913
Rv0761cadhB0.913
Rv0761cadhB0.913
Rv0162cadhE10.911
Rv0162cadhE10.911
Rv3252calkB0.911
Rv0753cmmsA0.909
Rv0860fadB0.909
Rv0860fadB0.909
Rv0860fadB0.909
Rv3170aofH0.907
Rv1530adh0.902
Rv1530adh0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.97663.425
acetaldehydePubChem0.95644.0526
acetatePubChem0.94559.044
octanalPubChem0.925128.212
coenzyme APubChem0.911767.534
gamma-aminobutyric acidPubChem0.91103.12
beta-alaninePubChem0.90589.0932
N-acetyl-gamma-aminobutyraldehydePubChem0.905129.157
auxinPubChem0.903174.176
reduced nicotinamide adenine dinucleotidePubChem0.903665.441
indole-3-acetaldehydePubChem0.903159.185
deuteriumPubChem0.9022.01588
5-hydroxyindole-3-acetaldehydePubChem0.902175.184
H(+)PubChem0.9012.01588
pyrophosphatePubChem0.901177.975
adenosine monophosphatePubChem0.901347.221
CO8PubChem0.9893.73
3-chloro-2-PropenalPubChem0.990.5083
C06002PubChem0.9102.089
octanoyl-CoAPubChem0.9893.73
hydroxyl radicalsPubChem0.917.0073
glyceratePubChem0.9106.077
Co-APubChem0.9767.534
perillic acidPubChem0.9166.217
adenosine triphosphatePubChem0.9507.181
protiumPubChem0.92.01576
methylmalonate semialdehydePubChem0.9102.089
C16348PubChem0.990.5083
octanoatePubChem0.9144.211
octanolPubChem0.9130.228
dihydronicotinamide formycin dinucleotidePubChem0.9665.441