Rv3170

Tuberculist information
Gene nameaofH
Protein functionProbable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3538.5
Molecular mass(da)48407.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 448
	  		  	1    VTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGRSLTGRVAGVPADMGG   60
			  	61   SFIGPTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSYRGTIPKLSLTGLIDIGRLR  120
			  	121  WQFERIARGVPVAAPWDARRARELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDD  180
			  	181  VSMLHAARYVRAAGGLDRLLDVKNGAQQDRVPGGTQQIAQAAAAQLGARVLLNAAVRRID  240
			  	241  RHGAGVTVTSDQGQAEAGFVIVAIPPAHRVAIEFDPPLPPEYQQLAHHWPQGRLSKAYAA  300
			  	301  YSTPFWRASGYSGQALSDEAPVFITFDVSPHADGPGILMGFVDARGFDSLPIEERRRDAL  360
			  	361  RCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWAST  420
			  	421  ETADEWTGYFDGAVRSGQRAAAEVAALL

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 23 to 451  |  Coverage: 95% Amino_oxidase Range: 6 to 448  |  Coverage: 98% 1 Range: 1 to 448  |  Coverage: 99% 1 Range: 5 to 53  |  Coverage: 10% 2 Range: 182 to 404  |  Coverage: 49% 3 Range: 93 to 204  |  Coverage: 24% 4 Range: 1 to 85  |  Coverage: 18% 5
Number of amino acids : 448
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Amino_oxidasePF0159323-451
Mtb Structural Proteome models
Model Number1
Model nameRv3170
Template1S3E    APDBCREDO
Template coverage3_454
Template Identity(%)36.8
Model coverage(%)98.7
Normalized DOPE score-0.91

Structure Models from Chopin
Model Number1
Profile1.10.405.10, 3.50.50.60, 3.90.660.10
Click for model details
zscore63.06
Residue begin1
Residue end448
Model Number2
Profilec.3.1.6 - 3.50.50.60
Click for model details
zscore13.1
Residue begin5
Residue end53
Model Number3
Profile3.90.660.10
Click for model details
zscore9.03
Residue begin182
Residue end404
Model Number4
Profile1.10.405.10
Click for model details
zscore8.5
Residue begin93
Residue end204
Model Number5
Profilec.5.1.1
Click for model details
zscore8.44
Residue begin1
Residue end85
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3170Gene nameConfidence Score
Rv0147Rv01470.937
Rv1703cRv1703c0.936
Rv2858caldC0.913
Rv0768aldA0.908
Rv0458Rv04580.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
norepinephrinePubChem0.981169.178
phenylethylaminePubChem0.98121.18
dopaminePubChem0.98153.178
flavin adenine dinucleotidePubChem0.979785.55
serotoninPubChem0.977176.215
tyraminePubChem0.971137.179
clorgylinePubChem0.946272.17
hydrogen peroxidePubChem0.9434.0147
selegilinePubChem0.934187.281
ammoniaPubChem0.92917.0305
3,4-dihydroxyphenylglycolaldehydePubChem0.925168.147
3-methoxytyraminePubChem0.921167.205
normetanephrinePubChem0.92183.204
p-hydroxyphenylacetaldehydePubChem0.915136.148
epinephrinePubChem0.91183.204
phenylacetaldehydePubChem0.907120.149
deuteriumPubChem0.9042.01588
metanephrinePubChem0.904197.231
protiumPubChem0.9022.01576
molecular oxygenPubChem0.931.9988
L-metanephrinePubChem0.9197.231
N-acetyl-gamma-aminobutyraldehydePubChem0.9129.157
an aldehydePubChem0.930.026
CDP-cholinePubChem0.9489.332
methylglyoxalPubChem0.972.0627
hydroxyl radicalsPubChem0.917.0073
L-normetanephrinePubChem0.9183.204
indole-3-acetaldehydePubChem0.9159.185
H(+)PubChem0.92.01588
5-hydroxyindole-3-acetaldehydePubChem0.9175.184
methanolPubChem0.930.026
isatinPubChem0.879147.131
pargylinePubChem0.864159.228
phenelzinePubChem0.854136.194
harminePubChem0.841248.708
rasagilinePubChem0.808171.238
2-(2-benzofuranyl)-2-imidazolinePubChem0.796186.21
moclobemidePubChem0.787268.739
tranylcyprominePubChem0.784133.19
iproniazidPubChem0.779179.219
MDL 72,974PubChem0.778197.224
benzylaminePubChem0.778107.153
amphetaminePubChem0.774135.206
befloxatonePubChem0.768349.302
N-methyl-N-propargyl-1(R)-aminoindanPubChem0.761221.726
Ro 19-6327PubChem0.758199.637
toloxatonePubChem0.748207.226
AGN 1135PubChem0.729171.238
L-dopaPubChem0.703197.188