Rv1703c

Tuberculist information
Gene nameRv1703c
Protein functionProbable catechol-O-methyltransferase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1929.13
Molecular mass(da)21537.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 196
	  		  	1    VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR   60
			  	61   VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD  120
			  	121  HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE  180
			  	181  YQTLVPDLVLESEYLG

Known structures in the PDB
No Known structures
1 20 39 58 77 96 115 134 153 172 191 Range: 1 to 176  |  Coverage: 89% Methyltransf_3 Range: 1 to 196  |  Coverage: 99% 1 Range: 1 to 196  |  Coverage: 99% 1
Number of amino acids : 196
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Methyltransf_3PF015961-176
Mtb Structural Proteome models
Model Number1
Model nameRv1703c
Template2CL5    APDBCREDO
Template coverage25_214
Template Identity(%)38.4
Model coverage(%)99.5
Normalized DOPE score-0.742

Structure Models from Chopin
Model Number1
Profilec.66.1.1 - 3.40.50.150
Click for model details
zscore30.95
Residue begin1
Residue end196
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1703cGene nameConfidence Score
Rv3170aofH0.936
Rv0761cadhB0.904
Rv0761cadhB0.904
Rv0761cadhB0.904
Rv0162cadhE10.902
Rv0162cadhE10.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
dopaminePubChem0.974153.178
norepinephrinePubChem0.972169.178
epinephrinePubChem0.943183.204
3-methoxytyraminePubChem0.939167.205
3,4-dihydroxyphenylglycolPubChem0.939170.163
normetanephrinePubChem0.939183.204
metanephrinePubChem0.939197.231
S-adenosyl-L-methioninePubChem0.901399.445
L-normetanephrinePubChem0.9183.204
L-metanephrinePubChem0.9197.231
3,5-dinitrocatecholPubChem0.89198.09
entacaponePubChem0.837305.286
tolcaponePubChem0.835273.241
nitecaponePubChem0.803265.219
1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanonePubChem0.785273.241
catecholPubChem0.731110.111
magnesiumPubChem0.72824.305
L-dopaPubChem0.704197.188