Rv0768

Tuberculist information
Gene namealdA
Protein functionProbable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+])
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)860.912
Molecular mass(da)51183.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 489
	  		  	1    MALWGDGISALLIDGKLSDGRAGTFPTVNPATEEVLGVAADADAEDMGRAIEAARRAFDS   60
			  	61   TDWSRNTELRVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTASAQLEGPVGDLSFAAD  120
			  	121  TAESYPWKQDLGEASPLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTV  180
			  	181  VLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTA  240
			  	241  TGRAVMADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACMHAGQGCAITTRLV  300
			  	301  VPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFAC  360
			  	361  GGARPADREVGFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGL  420
			  	421  SGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLE  480
			  	481  AKLIATAAN

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 17 to 484  |  Coverage: 95% Aldedh Range: 9 to 486  |  Coverage: 97% 1 Range: 1 to 489  |  Coverage: 99% 1 Range: 259 to 467  |  Coverage: 42% 2
Number of amino acids : 489
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AldedhPF0017117-484
Mtb Structural Proteome models
Model Number1
Model nameRv0768
Template1AG8    APDBCREDO
Template coverage20_493
Template Identity(%)36.7
Model coverage(%)97.5
Normalized DOPE score-0.443

Structure Models from Chopin
Model Number1
Profilec.82.1.1
Click for model details
zscore54.85
Residue begin1
Residue end489
Model Number2
Profile3.40.309.10
Click for model details
zscore41.78
Residue begin259
Residue end467
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0768Gene nameConfidence Score
Rv3535chsaG0.971
Rv3535chsaG0.971
Rv0409ackA0.96
Rv3667acs0.944
Rv3667acs0.944
Rv0761cadhB0.938
Rv0761cadhB0.938
Rv0761cadhB0.938
Rv2589gabT0.937
Rv3432cgadB0.931
Rv0751cmmsB0.921
Rv0751cmmsB0.921
Rv0753cmmsA0.912
Rv0853cpdc0.912
Rv0853cpdc0.912
Rv0853cpdc0.912
Rv1530adh0.911
Rv1530adh0.911
Rv3252calkB0.91
Rv3601cpanD0.908
Rv3170aofH0.908
Rv1862adhA0.907
Rv1862adhA0.907
Rv0860fadB0.906
Rv0860fadB0.906
Rv0860fadB0.906
Rv0162cadhE10.904
Rv0162cadhE10.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetaldehydePubChem0.9544.0526
acetatePubChem0.94159.044
gamma-aminobutyric acidPubChem0.913103.12
N-acetyl-gamma-aminobutyraldehydePubChem0.904129.157
indole-3-acetaldehydePubChem0.903159.185
beta-alaninePubChem0.90389.0932
auxinPubChem0.902174.176
3-chloro-2-PropenalPubChem0.990.5083
methylmalonate semialdehydePubChem0.9102.089
C16348PubChem0.990.5083
perillic acidPubChem0.9166.217
5-hydroxyindole-3-acetaldehydePubChem0.9175.184
glyceratePubChem0.9106.077
C06002PubChem0.9102.089
NADPPubChem0.746744.413
NAD+PubChem0.708663.425