Rv1530

Tuberculist information
Gene nameadh
Protein functionProbable alcohol dehydrogenase Adh
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1731.37
Molecular mass(da)37996.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 367
	  		  	1    MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHEQYTGELAGGFAF   60
			  	61   VPGHETVGTIAAIGPRAEQRWGVSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMY  120
			  	121  GFIPVDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNPLGAGIRWGVTIPETKP  180
			  	181  GDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQFGADLAVDVAIDDP  240
			  	241  VAALTEQTGGLADVVVDVTAKAPAAFAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVV  300
			  	301  FKELRVLGALGVDATAYRAALDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGERDGVPP  360
			  	361  IHGVLTP

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 30 to 150  |  Coverage: 32% ADH_N Range: 192 to 326  |  Coverage: 36% ADH_zinc_N Range: 5 to 357  |  Coverage: 95% 1 Range: 1 to 367  |  Coverage: 99% 1 Range: 30 to 150  |  Coverage: 32% 2 Range: 1 to 338  |  Coverage: 91% 3 Range: 192 to 326  |  Coverage: 36% 4
Number of amino acids : 367
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ADH_NPF0824030-150
ADH_zinc_NPF00107192-326
Mtb Structural Proteome models
Model Number1
Model nameRv1530
Template1LLU    APDBCREDO
Template coverage10_336
Template Identity(%)33.0
Model coverage(%)95.7
Normalized DOPE score0.21

Structure Models from Chopin
Model Number1
Profile3.40.50.720, 3.90.180.10
Click for model details
zscore26.46
Residue begin1
Residue end367
Model Number2
Profile3.90.180.10
Click for model details
zscore17.01
Residue begin30
Residue end150
Model Number3
Profile3.90.180.10
Click for model details
zscore14.49
Residue begin1
Residue end338
Model Number4
Profilec.2.1.1
Click for model details
zscore13.27
Residue begin192
Residue end326
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1530Gene nameConfidence Score
Rv1531Rv15310.965
Rv0768aldA0.911
Rv0223cRv0223c0.91
Rv0458Rv04580.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.933663.425
acetaldehydePubChem0.91444.0526
methanolPubChem0.90230.026
3,4-dihydroxyphenylglycolaldehydePubChem0.9168.147
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
1-naphthalenecarboxaldehydePubChem0.9156.181
protiumPubChem0.92.01576
1-hydroxymethylnaphthalenePubChem0.9158.197
2-hydroxymethylnaphthalenePubChem0.9158.197
deuteriumPubChem0.92.01588
trans-3-chloroallyl alcoholPubChem0.992.5242
H(+)PubChem0.92.01588
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
NSC508744PubChem0.992.5242
2-naphthaldehydePubChem0.9156.181
C16348PubChem0.990.5083
3-chloro-2-PropenalPubChem0.990.5083
3,4-dihydroxyphenylglycolPubChem0.9170.163