Rv0853c

Tuberculist information
Gene namepdc
Protein functionProbable pyruvate or indole-3-pyruvate decarboxylase Pdc
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)949.436
Molecular mass(da)59751.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 560
	  		  	1    VTPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAHPTIRWVGSAN   60
			  	61   ELNAGYAADGYGRLRGMSAVVTTFGVGELSVTNAIAGSYAEHVPVVHIVGGPTKDAQGTR  120
			  	121  RALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDRVLSEVREQKRPGYILLSSDV  180
			  	181  ARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEAL  240
			  	241  LAADVVPHATLMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVS  300
			  	301  GFFSQRIDPARTIDIGQYQSSVADQVFAPLEMSAALQALATILTGRGISSPPVVPPPAEP  360
			  	361  PPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYGMADHRLPQGVTFIGQPLWGS  420
			  	421  IGYTLPAAVGAAVAHPDRRTVLLIGDGAAQLTVQELGTFSREGLSPVIVVVNNDGYTVER  480
			  	481  AIHGETAPYNDIVSWNWTELPSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVV  540
			  	541  LPRLEIPRLLGQLVGSMAPQ

Known structures in the PDB
PDB ID3L60
Total residue count250
Number of chains1
MethodX-RAY
Resolution2
1 57 113 169 225 281 337 393 449 505 561 Range: 14 to 189  |  Coverage: 31% TPP_enzyme_N Range: 208 to 343  |  Coverage: 24% TPP_enzyme_M Range: 393 to 539  |  Coverage: 26% TPP_enzyme_C Range: 14 to 559  |  Coverage: 97% 1 Range: 4 to 560  |  Coverage: 99% 1 Range: 2 to 206  |  Coverage: 36% 2 Range: 393 to 539  |  Coverage: 26% 3 Range: 208 to 343  |  Coverage: 24% 4 Range: 359 to 560  |  Coverage: 35% 5 Range: 188 to 377  |  Coverage: 33% 6
Number of amino acids : 560
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TPP_enzyme_NPF0277614-189
TPP_enzyme_MPF00205208-343
TPP_enzyme_CPF02775393-539
Mtb Structural Proteome models
Model Number1
Model nameRv0853c
Template1OVM    APDBCREDO
Template coverage5_548
Template Identity(%)47.7
Model coverage(%)97.3
Normalized DOPE score-0.803

Structure Models from Chopin
Model Number1
Profile3.40.50.1220, 3.40.50.970
Click for model details
zscore66.32
Residue begin4
Residue end560
Model Number2
Profilec.36.1.5
Click for model details
zscore44.23
Residue begin2
Residue end206
Model Number3
Profilec.36.1.9
Click for model details
zscore30.01
Residue begin393
Residue end539
Model Number4
Profilec.31.1.3
Click for model details
zscore24.14
Residue begin208
Residue end343
Model Number5
Profilec.36.1.9
Click for model details
zscore17.91
Residue begin359
Residue end560
Model Number6
Profilec.31.1.3
Click for model details
zscore10.92
Residue begin188
Residue end377
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0853cGene nameConfidence Score
Rv0147Rv01470.93
Rv0458Rv04580.923
Rv2858caldC0.918
Rv0768aldA0.912
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
indole-3-pyruvic acidPubChem0.973203.194
auxinPubChem0.963174.176
indole-3-acetaldehydePubChem0.961159.185
carbon dioxidePubChem0.94544.0095
L-tryptophanPubChem0.928204.225
thiamine pyrophosphatePubChem0.917425.314
glutamatePubChem0.914147.129
alpha-ketoglutaratePubChem0.905146.098
deuteriumPubChem0.9032.01588
hydroxyl radicalsPubChem0.90317.0073
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
hydrogen peroxidePubChem0.934.0147
magnesiumPubChem0.924.305
molecular oxygenPubChem0.931.9988
thiaminePubChem0.842265.355
ethanolPubChem0.80746.0684
acetatePubChem0.72359.044
pyruvic acidPubChem0.70788.0621
acetaldehydePubChem0.70544.0526