Rv2858c

Tuberculist information
Gene namealdC
Protein functionProbable aldehyde dehydrogenase AldC
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3169.36
Molecular mass(da)48258.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 455
	  		  	1    MSTTQLINPATEEVLASVDHTDANAVDDAVQRARAAQRRWARLAPAQRAAGLRAFAAAVQ   60
			  	61   AHLDELAALEVANSGHPIVSAEWEAGHVRDVLAFYAASPERLSGRQIPVAGGVDVTFNEP  120
			  	121  MGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLTTMRLGELAVEAGLDEDLL  180
			  	181  QVLPGKGTVVGERFVTHPDIRKIVFTGSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFH  240
			  	241  DCDLERAATTAPAGVFDNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRAT  300
			  	301  EMGPLVSRAHRDKVAGYVPDDAPVAFRGTAPAGRGFWFPPTVLTPKRGDRTVTDEIFGPV  360
			  	361  VVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAVESGNLSVNSHSSVRFNTP  420
			  	421  FGGFKQSGVGRELGPDAPLQFTETKNVFIAVGEEM

Known structures in the PDB
No Known structures
1 46 91 136 181 226 271 316 361 406 451 Range: 2 to 447  |  Coverage: 97% Aldedh Range: 4 to 454  |  Coverage: 98% 1 Range: 1 to 455  |  Coverage: 99% 1 Range: 229 to 430  |  Coverage: 44% 2
Number of amino acids : 455
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AldedhPF001712-447
Mtb Structural Proteome models
Model Number1
Model nameRv2858c
Template1BXS    APDBCREDO
Template coverage37_498
Template Identity(%)39.0
Model coverage(%)98.7
Normalized DOPE score-0.67

Structure Models from Chopin
Model Number1
Profilec.82.1.1
Click for model details
zscore55.88
Residue begin1
Residue end455
Model Number2
Profile3.40.309.10
Click for model details
zscore37.58
Residue begin229
Residue end430
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2858cGene nameConfidence Score
Rv3535chsaG0.975
Rv3535chsaG0.975
Rv0409ackA0.96
Rv3667acs0.95
Rv3667acs0.95
Rv2589gabT0.94
Rv3432cgadB0.937
Rv0751cmmsB0.926
Rv0751cmmsB0.926
Rv0853cpdc0.918
Rv0853cpdc0.918
Rv0853cpdc0.918
Rv0753cmmsA0.914
Rv3170aofH0.913
Rv3252calkB0.91
Rv1862adhA0.909
Rv1862adhA0.909
Rv0860fadB0.907
Rv0860fadB0.907
Rv3601cpanD0.907
Rv0860fadB0.907
Rv2860cglnA40.906
Rv2860cglnA40.906
Rv0761cadhB0.905
Rv0162cadhE10.905
Rv0761cadhB0.905
Rv0162cadhE10.905
Rv0761cadhB0.905
Rv2205cRv2205c0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetaldehydePubChem0.95544.0526
acetatePubChem0.94159.044
gamma-aminobutyric acidPubChem0.912103.12
N-acetyl-gamma-aminobutyraldehydePubChem0.905129.157
beta-alaninePubChem0.90589.0932
auxinPubChem0.904174.176
indole-3-acetaldehydePubChem0.902159.185
3-chloro-2-PropenalPubChem0.990.5083
methylmalonate semialdehydePubChem0.9102.089
C16348PubChem0.990.5083
perillic acidPubChem0.9166.217
5-hydroxyindole-3-acetaldehydePubChem0.9175.184
glyceratePubChem0.9106.077
C06002PubChem0.9102.089