SInCRe - Rv2205c

Tuberculist information

Gene name	Rv2205c
Protein function	Conserved hypothetical protein
Functional category(tuberculist)	conserved hypotheticals
Gene location(kb)	2469.39
Molecular mass(da)	35592.6
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 358

	  		  	1    MRVLVAPDCYGDSLSAVEAAAAIATGWTRSRPGDSFIVAPQSDGGPGFVEVLGSRLGETR   60
			  	61   RLRVCGPLNTVVNAAWVFDPGSATAYLECAQACGLGLLGGPPTPETALAAHSKGVGQLIA  120
			  	121  AALRAGAARIVVGLGGSACTDGGKGMIAELGGLDAARRQLADVEVIAASDVEYPLLGPWG  180
			  	181  TARVFAPQKGADMATVAVLEGRLAAWAIELDAAAGRGVSAEPGAGAAGGIGAGLLAVGGR  240
			  	241  YQSGAAIIAEHTHFADDLADAELIVTGEGRFDEQSLHGKVVGAIAAAARPLAIPVIVLAG  300
			  	301  QVSLDKSALRSAGIMAALSIAEYAGSVRLALADAANQLMGLASQVAARLGNSGPSGYR

Known structures in the PDB

No Known structures

Number of amino acids : 358

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Gly_kinase	PF02595	1-354

Mtb Structural Proteome models

Model Number	1
Model name	Rv2205c
Template	1TO6 APDB CREDO
Template coverage	1_368
Template Identity(%)	28.8
Model coverage(%)	97.8
Normalized DOPE score	0.63

Structure Models from Chopin

Model Number	1
Profile	c.141.1.1 Click for model details
zscore	52.67
Residue begin	1
Residue end	354

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2205c	Gene name	Confidence Score
Rv1023	eno	0.95
Rv1023	eno	0.95
Rv0728c	serA2	0.933
Rv0728c	serA2	0.933
Rv2996c	serA1	0.924
Rv2996c	serA1	0.924
Rv2996c	serA1	0.924
Rv3214	gpm2	0.918
Rv0489	gpm1	0.914
Rv2419c	Rv2419c	0.912
Rv2858c	aldC	0.904
Rv0147	Rv0147	0.902

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
glyceratePubChem	0.915	106.077
2-phospho-D-glyceratePubChem	0.9	186.057
hydroxypyruvatePubChem	0.9	104.061
(2S)-3-hydroxy-2-phosphato-propionatePubChem	0.9	183.033
adenosine diphosphatePubChem	0.9	427.201
3-phosphoglyceratePubChem	0.9	186.057
H(+)PubChem	0.9	2.01588
deuteriumPubChem	0.9	2.01588
protiumPubChem	0.9	2.01576
phosphoglyceratePubChem	0.9	186.057
adenosine triphosphatePubChem	0.9	507.181