SInCRe - Rv2419c

Tuberculist information

Gene name	gpgP
Protein function	Glucosyl-3-phosphoglycerate phosphatase GpgP
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	2717.13
Molecular mass(da)	24174.3
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 223

	  		  	1    MRARRLVMLRHGQTDYNVGSRMQGQLDTELSELGRTQAVAAAEVLGKRQPLLIVSSDLRR   60
			  	61   AYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLTHAQIDADAPGARLAWREDATWAPHGG  120
			  	121  ESRVDVAARSRPLVAELVASEPEWGGADEPDRPVVLVAHGGLIAALSAALLKLPVANWPA  180
			  	181  LGGMGNASWTQLSGHWAPGSDFESIRWRLDVWNASAQVSSDVL

Known structures in the PDB

	PDB ID	4PZ9
	Total residue count	446
	Number of chains	2
	Method	X-RAY
	Resolution	1.94

	PDB ID	4PZA
	Total residue count	446
	Number of chains	2
	Method	X-RAY
	Resolution	1.78

	PDB ID	4QIH
	Total residue count	446
	Number of chains	2
	Method	X-RAY
	Resolution	2.3

Number of amino acids : 223

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
His_Phos_1	PF00300	5-166

Mtb Structural Proteome models

Model Number	1
Model name	Rv2419c
Template	1H2E APDB CREDO
Template coverage	2_204
Template Identity(%)	31.0
Model coverage(%)	97.3
Normalized DOPE score	-0.595

Structure Models from Chopin

Model Number	1
Profile	c.60.1.4 - 3.40.50.1240 Click for model details
zscore	33
Residue begin	4
Residue end	211

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2419c	Gene name	Confidence Score
Rv1437	pgk	0.952
Rv1023	eno	0.936
Rv1023	eno	0.936
Rv2205c	Rv2205c	0.912
Rv0728c	serA2	0.908
Rv0728c	serA2	0.908
Rv2996c	serA1	0.901
Rv2996c	serA1	0.901
Rv2996c	serA1	0.901

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
phosphoglyceratePubChem	0.925	186.057
3-phosphoglyceratePubChem	0.91	186.057
2-phospho-D-glyceratePubChem	0.9	186.057
glyceratePubChem	0.9	106.077
(2S)-3-hydroxy-2-phosphato-propionatePubChem	0.9	183.033
NADPPubChem	0.9	744.413
adenosine diphosphatePubChem	0.9	427.201
hydroxyl radicalsPubChem	0.9	17.0073
glyceraldehyde-3-phosphatePubChem	0.9	170.058
1,3-diphosphoglyceratePubChem	0.9	266.037
1,3-bisphospho-d-glyceratePubChem	0.9	266.037
D-glyceraldehyde-3-phosphatePubChem	0.9	170.058
protiumPubChem	0.9	2.01576
deuteriumPubChem	0.9	2.01588
NADP(H)PubChem	0.9	745.421
1,3-bisphosphoglyceratePubChem	0.9	266.037
adenosine triphosphatePubChem	0.9	507.181
phosphoenolpyruvatePubChem	0.9	168.042
H(+)PubChem	0.9	2.01588