Rv1023

Tuberculist information
Gene nameeno
Protein functionProbable enolase Eno
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1144.56
Molecular mass(da)44929.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 429
	  		  	1    VPIIEQVRAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGEHEAVELRDGGDRYGG   60
			  	61   KGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKA  120
			  	121  AADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVDIQEFMVAPIGAPSFVEALRW  180
			  	181  GAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLISRAIESAGLRPGADVALAL  240
			  	241  DAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTAS  300
			  	301  IGDRVQIVGDDIFVTNPERLEEGIERGVANALLVKVNQIGTLTETLDAVTLAHHGGYRTM  360
			  	361  ISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKYNQLLRIEEALGDAARYAGDLA  420
			  	421  FPRFACETK

Known structures in the PDB
No Known structures
1 43 85 127 169 211 253 295 337 379 421 Range: 3 to 133  |  Coverage: 30% Enolase_N Range: 138 to 423  |  Coverage: 66% Enolase_C Range: 2 to 419  |  Coverage: 97% 1 Range: 1 to 421  |  Coverage: 97% 1 Range: 138 to 423  |  Coverage: 66% 2 Range: 3 to 133  |  Coverage: 30% 3
Number of amino acids : 429
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Enolase_NPF039523-133
Enolase_CPF00113138-423
Mtb Structural Proteome models
Model Number1
Model nameRv1023
Template2FYM    APDBCREDO
Template coverage1_425
Template Identity(%)55.7
Model coverage(%)97.2
Normalized DOPE score-1.24

Structure Models from Chopin
Model Number1
Profilec.1.11.1, d.54.1.1
Click for model details
zscore79.68
Residue begin1
Residue end421
Model Number2
Profilec.1.11.1
Click for model details
zscore53.92
Residue begin138
Residue end423
Model Number3
Profiled.54.1.1
Click for model details
zscore10.07
Residue begin3
Residue end133
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1023Gene nameConfidence Score
Rv1437pgk0.999
Rv1617pykA0.999
Rv1617pykA0.999
Rv0489gpm10.998
Rv1438tpi0.997
Rv1436gap0.995
Rv1436gap0.995
Rv0946cpgi0.993
Rv0363cfba0.99
Rv1449ctkt0.986
Rv1449ctkt0.986
Rv3459crpsK0.986
Rv1449ctkt0.986
Rv1699pyrG0.982
Rv1699pyrG0.982
Rv3010cpfkA0.982
Rv0721rpsE0.977
Rv0721rpsE0.977
Rv1448ctal0.975
Rv3458crpsD0.974
Rv3458crpsD0.974
Rv0350dnaK0.974
Rv0716rplE0.972
Rv0716rplE0.972
Rv3457crpoA0.971
Rv1310atpD0.971
Rv1310atpD0.971
Rv1310atpD0.971
Rv3457crpoA0.971
Rv3457crpoA0.971
Rv3460crpsM0.97
Rv0714rplN0.966
Rv0704rplB0.965
Rv0704rplB0.965
Rv1240mdh0.963
Rv1240mdh0.963
Rv1308atpA0.962
Rv2889ctsf0.962
Rv2889ctsf0.962
Rv0211pckA0.962
Rv1308atpA0.962
Rv1308atpA0.962
Rv3442crpsI0.959
Rv0478deoC0.958
Rv2783cgpsI0.957
Rv2783cgpsI0.957
Rv2783cgpsI0.957
Rv2783cgpsI0.957
Rv2783cgpsI0.957
Rv3834cserS0.955
Rv3834cserS0.955
Rv3674cnth0.954
Rv3674cnth0.954
Rv3674cnth0.954
Rv0684fusA10.952
Rv0684fusA10.952
Rv0684fusA10.952
Rv0684fusA10.952
Rv0684fusA10.952
Rv0719rplF0.951
Rv0070cglyA20.951
Rv2205cRv2205c0.95
Rv1093glyA10.949
Rv2614cthrS0.947
Rv2614cthrS0.947
Rv2614cthrS0.947
Rv0640rplK0.946
Rv0640rplK0.946
Rv1844cgnd10.944
Rv1844cgnd10.944
Rv2462ctig0.943
Rv2462ctig0.943
Rv2462ctig0.943
Rv3014cligA0.942
Rv3014cligA0.942
Rv3014cligA0.942
Rv3014cligA0.942
Rv3014cligA0.942
Rv1536ileS0.939
Rv1536ileS0.939
Rv1383carA0.938
Rv1383carA0.938
Rv0682rpsL0.937
Rv0668rpoC0.937
Rv0668rpoC0.937
Rv0668rpoC0.937
Rv0668rpoC0.937
Rv0668rpoC0.937
Rv2419cRv2419c0.936
Rv3628ppa0.936
Rv2496cbkdB0.935
Rv2883cpyrH0.935
Rv2496cbkdB0.935
Rv1309atpG0.935
Rv2890crpsB0.935
Rv2445cndkA0.933
Rv3846sodA0.932
Rv3846sodA0.932
Rv0700rpsJ0.931
Rv0056rplI0.928
Rv0056rplI0.928
Rv0685tuf0.927
Rv0685tuf0.927
Rv0685tuf0.927
Rv2737crecA0.926
Rv2737crecA0.926
Rv0641rplA0.924
Rv1633uvrB0.922
Rv1633uvrB0.922
Rv1633uvrB0.922
Rv1633uvrB0.922
Rv0667rpoB0.921
Rv1098cfum0.921
Rv0667rpoB0.921
Rv1098cfum0.921
Rv0667rpoB0.921
Rv0667rpoB0.921
Rv0667rpoB0.921
Rv0667rpoB0.921
Rv0707rpsC0.92
Rv0707rpsC0.92
Rv3709cask0.92
Rv3709cask0.92
Rv3709cask0.92
Rv0652rplL0.919
Rv3214gpm20.919
Rv0701rplC0.917
Rv0462lpdC0.915
Rv0462lpdC0.915
Rv0462lpdC0.915
Rv3443crplM0.914
Rv0952sucD0.912
Rv0952sucD0.912
Rv0732secY0.912
Rv0683rpsG0.91
Rv3456crplQ0.91
Rv2448cvalS0.909
Rv2448cvalS0.909
Rv2448cvalS0.909
Rv2697cdut0.909
Rv0718rpsH0.909
Rv3356cfolD0.907
Rv0723rplO0.907
Rv0733adk0.907
Rv3356cfolD0.907
Rv1017cprsA0.906
Rv1017cprsA0.906
Rv2992cgltS0.904
Rv1014cpth0.902
Rv2192ctrpD0.901
Rv2192ctrpD0.901
Rv3914trxC0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphoenolpyruvatePubChem0.995168.042
magnesiumPubChem0.99424.305
phosphatePubChem0.98896.9872
phosphoglyceratePubChem0.986186.057
2-phospho-D-glyceratePubChem0.98186.057
carbon dioxidePubChem0.96144.0095
3-phosphoglyceratePubChem0.951186.057
oxaloacetatePubChem0.942132.072
hydroxyl radicalsPubChem0.92617.0073
adenosine triphosphatePubChem0.912507.181
deuteriumPubChem0.9112.01588
pyruvic acidPubChem0.90888.0621
H(+)PubChem0.9072.01588
adenosine monophosphatePubChem0.9347.221
(2S)-3-hydroxy-2-phosphato-propionatePubChem0.9183.033
protiumPubChem0.92.01576
adenosine diphosphatePubChem0.9427.201
sulfatePubChem0.8796.0626
phosphonoacetohydroxamatePubChem0.828155.046
polyethylene glycolPubChem0.80962.0678
hydron sulfatePubChem0.793196.157
fluoridePubChem0.79220.0063
2-propylglutaric acidPubChem0.792174.194
2,3-diketo-5-methylthiopentyl-1-phosphatePubChem0.788242.187
ribulose-1,5-bisphosphatePubChem0.768310.09
ribulose 1,5-bisphosphatePubChem0.764310.09
methylthioadenosinePubChem0.761297.333
5'-deoxy-5'-methylthioadenosinePubChem0.756297.333
zincPubChem0.73765.409
ethylene glycol; hydronPubChem0.73663.0758
glyceraldehydePubChem0.73290.0779
5-methylthioribulose-1-phosphatePubChem0.732260.202
hydron diphosphatePubChem0.729391.981
OFLPubChem0.714281.23
2PEPubChem0.712414.488
FSGPubChem0.708173.037
2pu1PubChem0.708171.021
lactatePubChem0.70190.0779