Rv3834c

Tuberculist information
Gene nameserS
Protein functionSERYL-tRNA synthetase SerS (serine--tRNA ligase) (SERRS) (serine translase)
Functional category(tuberculist)information pathways
Gene location(kb)4307.65
Molecular mass(da)45292.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 419
	  		  	1    VIDLKLLRENPDAVRRSQLSRGEDPALVDALLTADAARRAVISTADSLRAEQKAASKSVG   60
			  	61   GASPEERPPLLRRAKELAEQVKAAEADEVEAEAAFTAAHLAISNVIVDGVPAGGEDDYAV  120
			  	121  LDVVGEPSYLENPKDHLELGESLGLIDMQRGAKVSGSRFYFLTGRGALLQLGLLQLALKL  180
			  	181  AVDNGFVPTIPPVLVRPEVMVGTGFLGAHAEEVYRVEGDGLYLVGTSEVPLAGYHSGEIL  240
			  	241  DLSRGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCTPADAEHEHERLLGW  300
			  	301  QRQMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWIPTQGAYRELTSTSNCTTFQARRLA  360
			  	361  TRYRDASGKPQIAATLNGTLATTRWLVAILENHQRPDGSVRVPDALVPFVGVEVLEPVA

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 1 to 106  |  Coverage: 25% Seryl_tRNA_N Range: 169 to 339  |  Coverage: 40% tRNA-synt_2b Range: 1 to 417  |  Coverage: 99% 1 Range: 1 to 111  |  Coverage: 26% 1
Number of amino acids : 419
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Seryl_tRNA_NPF024031-106
tRNA-synt_2bPF00587169-339
Mtb Structural Proteome models
Model Number1
Model nameRv3834c
Template1SES    APDBCREDO
Template coverage1_419
Template Identity(%)41.0
Model coverage(%)99.3
Normalized DOPE score-0.178

Structure Models from Chopin
Model Number1
Profilea.2.7.1
Click for model details
zscore22.81
Residue begin1
Residue end111
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3834cGene nameConfidence Score
Rv2614cthrS0.979
Rv2614cthrS0.979
Rv2614cthrS0.979
Rv1536ileS0.972
Rv1536ileS0.972
Rv3580ccysS10.971
Rv3580ccysS10.971
Rv1112Rv11120.969
Rv1112Rv11120.969
Rv2448cvalS0.968
Rv2448cvalS0.968
Rv2448cvalS0.968
Rv3336ctrpS0.967
Rv0041leuS0.966
Rv0041leuS0.966
Rv0041leuS0.966
Rv3598clysS0.966
Rv3598clysS0.966
Rv2440cobg0.965
Rv2440cobg0.965
Rv2440cobg0.965
Rv0005gyrB0.961
Rv0005gyrB0.961
Rv0005gyrB0.961
Rv0005gyrB0.961
Rv2992cgltS0.958
Rv0006gyrA0.955
Rv1023eno0.955
Rv0006gyrA0.955
Rv1023eno0.955
Rv2580chisS0.953
Rv2580chisS0.953
Rv2555calaS0.943
Rv2555calaS0.943
Rv2555calaS0.943
Rv3100csmpB0.936
Rv2584capt0.931
Rv2839cinfB0.928
Rv2130cmshC0.928
Rv2839cinfB0.928
Rv2839cinfB0.928
Rv2839cinfB0.928
Rv1292argS0.927
Rv1292argS0.927
Rv1292argS0.927
Rv2883cpyrH0.923
Rv1649pheS0.922
Rv1649pheS0.922
Rv1014cpth0.922
Rv3913trxB20.918
Rv3913trxB20.918
Rv1010ksgA0.917
Rv0704rplB0.915
Rv0704rplB0.915
Rv1638uvrA0.912
Rv1689tyrS0.909
Rv1689tyrS0.909
Rv3457crpoA0.908
Rv3457crpoA0.908
Rv3457crpoA0.908
Rv2093ctatC0.907
Rv0716rplE0.905
Rv0716rplE0.905
Rv1007cmetS0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine monophosphatePubChem0.978347.221
adenosine triphosphatePubChem0.967507.181
L-serinePubChem0.933105.093
pyrophosphatePubChem0.9177.975
SersaPubChem0.798433.397
silver nanoparticlesPubChem0.749107.868
sulfatePubChem0.73596.0626
Na(+)PubChem0.71622.9898
serine hydroxamatePubChem0.708120.107
hydron sulfatePubChem0.707196.157
selenomethioninePubChem0.704196.106
SeMetPubChem0.704196.106