Rv3913

Tuberculist information
Gene nametrxB2
Protein functionProbable thioredoxin reductase TrxB2 (TRXR) (TR)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4401.73
Molecular mass(da)35643
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 335
	  		  	1    MTAPPVHDRAHHPVRDVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGGALMTTTDVEN   60
			  	61   YPGFRNGITGPELMDEMREQALRFGADLRMEDVESVSLHGPLKSVVTADGQTHRARAVIL  120
			  	121  AMGAAARYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTRFARS  180
			  	181  VTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTVVAVDGDTTVTGLRVRDTNTGAETTLP  240
			  	241  VTGVFVAIGHEPRSGLVREAIDVDPDGYVLVQGRTTSTSLPGVFAAGDLVDRTYRQAVTA  300
			  	301  AGSGCAAAIDAERWLAEHAATGEADSTDALIGAQR

Known structures in the PDB
PDB ID2A87
Total residue count670
Number of chains2
MethodX-RAY
Resolution3
1 34 67 100 133 166 199 232 265 298 331 Range: 16 to 294  |  Coverage: 82% Pyr_redox_2 Range: 157 to 233  |  Coverage: 22% Pyr_redox Range: 10 to 322  |  Coverage: 93% 1 Range: 10 to 322  |  Coverage: 93% 2 Range: 1 to 57  |  Coverage: 16% 1
Number of amino acids : 335
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pyr_redox_2PF0799216-294
Pyr_redoxPF00070157-233
Mtb Structural Proteome models
Model Number1
Model nameRv3913_2a87_A
Template2A87    APDBCREDO
Template coverage10_322
Template Identity(%)100.0
Model coverage(%)93.1
Normalized DOPE score-0.989

Model Number2
Model nameRv3913
Template2A87    APDBCREDO
Template coverage10_322
Template Identity(%)100.0
Model coverage(%)93.1
Normalized DOPE score-0.92

Structure Models from Chopin
Model Number1
Profilec.3.1.6 - 3.50.50.60
Click for model details
zscore9.78
Residue begin1
Residue end57
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3913Gene nameConfidence Score
Rv3914trxC0.999
Rv1471trxB10.999
Rv2428ahpC0.998
Rv1932tpx0.984
Rv1470trxA0.965
Rv1638uvrA0.949
Rv0056rplI0.942
Rv0056rplI0.942
Rv1464csd0.93
Rv0350dnaK0.927
Rv1420uvrC0.921
Rv1420uvrC0.921
Rv1420uvrC0.921
Rv1420uvrC0.921
Rv3834cserS0.918
Rv3834cserS0.918
Rv0733adk0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NADPPubChem0.998744.413
flavin adenine dinucleotidePubChem0.987785.55
hydrogen peroxidePubChem0.93434.0147
magnesiumPubChem0.92824.305
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
NADP(H)PubChem0.9745.421
H(+)PubChem0.92.01588
hydrazinePubChem0.75332.0452