SInCRe - Rv2428

Tuberculist information

Gene name	ahpC
Protein function	Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C)
Functional category(tuberculist)	virulence,detoxification and adaptaion
Gene location(kb)	2726.19
Molecular mass(da)	21566.3
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 195

	  		  	1    MPLLTIGDQFPAYQLTALIGGDLSKVDAKQPGDYFTTITSDEHPGKWRVVFFWPKDFTFV   60
			  	61   CPTEIAAFSKLNDEFEDRDAQILGVSIDSEFAHFQWRAQHNDLKTLPFPMLSDIKRELSQ  120
			  	121  AAGVLNADGVADRVTFIVDPNNEIQFVSATAGSVGRNVDEVLRVLDALQSDELCACNWRK  180
			  	181  GDPTLDAGELLKASA

Known structures in the PDB

	PDB ID	2BMX
	Total residue count	585
	Number of chains	3
	Method	X-RAY
	Resolution	2.4

Number of amino acids : 195

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
AhpC-TSA	PF00578	6-147

Mtb Structural Proteome models

Model Number	1
Model name	Rv2428_2bmx_A
Template	2BMX APDB CREDO
Template coverage	2_170
Template Identity(%)	100.0
Model coverage(%)	86.2
Normalized DOPE score	-2.276

Model Number	2
Model name	Rv2428
Template	2BMX APDB CREDO
Template coverage	2_170
Template Identity(%)	100.0
Model coverage(%)	86.2
Normalized DOPE score	-2.047

Structure Models from Chopin

Model Number	1
Profile	c.47.1.10 - 3.40.30.10 Click for model details
zscore	12.57
Residue begin	1
Residue end	195

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2428	Gene name	Confidence Score
Rv2429	ahpD	0.999
Rv3846	sodA	0.998
Rv3913	trxB2	0.998
Rv3913	trxB2	0.998
Rv3914	trxC	0.998
Rv3846	sodA	0.998
Rv2215	dlaT	0.982
Rv2215	dlaT	0.982
Rv2215	dlaT	0.982
Rv0432	sodC	0.981
Rv1908c	katG	0.976
Rv0682	rpsL	0.969
Rv0117	oxyS	0.966
Rv0117	oxyS	0.966
Rv0667	rpoB	0.965
Rv0667	rpoB	0.965
Rv0667	rpoB	0.965
Rv0667	rpoB	0.965
Rv0667	rpoB	0.965
Rv0667	rpoB	0.965
Rv1909c	furA	0.964
Rv0006	gyrA	0.954
Rv0006	gyrA	0.954
Rv2678c	hemE	0.953
Rv1471	trxB1	0.928
Rv3841	bfrB	0.92
Rv2043c	pncA	0.917
Rv1437	pgk	0.913

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
SeMetPubChem	0.954	196.106
hydrogen peroxidePubChem	0.948	34.0147
selenomethioninePubChem	0.948	196.106
NAD+PubChem	0.938	663.425
reduced nicotinamide adenine dinucleotidePubChem	0.933	665.441
hydroxyl radicalsPubChem	0.925	17.0073
cumene hydroperoxidePubChem	0.922	152.19
dihydronicotinamide formycin dinucleotidePubChem	0.9	665.441
methanolPubChem	0.9	30.026
peroxynitritePubChem	0.84	62.0049
isoniazidPubChem	0.812	137.139
cysteine sulfenic acidPubChem	0.784	137.158
tert-butyl hydroperoxidePubChem	0.782	90.121
rifampicinPubChem	0.75	822.94
paraquatPubChem	0.732	257.159
rifampin and isoniazidPubChem	0.718	960.08
MABAPubChem	0.712	137.136
sulfenic acidPubChem	0.702	49.0723