Rv2429

Tuberculist information
Gene nameahpD
Protein functionAlkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D)
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)2726.81
Molecular mass(da)18780.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 177
	  		  	1    MSIEKLKAALPEYAKDIKLNLSSITRSSVLDQEQLWGTLLASAAATRNPQVLADIGAEAT   60
			  	61   DHLSAAARHAALGAAAIMGMNNVFYRGRGFLEGRYDDLRPGLRMNIIANPGIPKANFELW  120
			  	121  SFAVSAINGCSHCLVAHEHTLRTVGVDREAIFEALKAAAIVSGVAQALATIEALSPS

Known structures in the PDB
PDB ID1GU9
Total residue count2124
Number of chains12
MethodX-RAY
Resolution1.9
PDB ID1KNC
Total residue count531
Number of chains3
MethodX-RAY
Resolution2
PDB ID1LW1
Total residue count531
Number of chains3
MethodX-RAY
Resolution2.3
PDB ID1ME5
Total residue count531
Number of chains3
MethodX-RAY
Resolution2.4
1 18 35 52 69 86 103 120 137 154 171 Range: 94 to 176  |  Coverage: 46% CMD Range: 2 to 175  |  Coverage: 97% 1 Range: 4 to 175  |  Coverage: 96% 2 Range: 2 to 175  |  Coverage: 97% 1 Range: 86 to 174  |  Coverage: 49% 2
Number of amino acids : 177
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CMDPF0262794-176
Mtb Structural Proteome models
Model Number1
Model nameRv2429_1knc_A
Template1KNC    APDBCREDO
Template coverage2_175
Template Identity(%)100.0
Model coverage(%)97.7
Normalized DOPE score-1.524

Model Number2
Model nameRv2429
Template1GU9    APDBCREDO
Template coverage4_175
Template Identity(%)100.0
Model coverage(%)96.6
Normalized DOPE score-1.148

Structure Models from Chopin
Model Number1
Profilea.152.1.1 - 1.20.1290.10
Click for model details
zscore36.54
Residue begin2
Residue end175
Model Number2
Profile1.20.1290.10
Click for model details
zscore10.19
Residue begin86
Residue end174
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2429Gene nameConfidence Score
Rv2428ahpC0.999
Rv2215dlaT0.984
Rv2215dlaT0.984
Rv2215dlaT0.984
Rv0462lpdC0.983
Rv0462lpdC0.983
Rv0462lpdC0.983
Rv1908ckatG0.918
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
SeMetPubChem0.9196.106
sulfatePubChem0.996.0626
hydron sulfatePubChem0.9196.157
selenomethioninePubChem0.9196.106