Rv2678c

Tuberculist information
Gene namehemE
Protein functionProbable uroporphyrinogen decarboxylase HemE (uroporphyrinogen III decarboxylase) (URO-D) (UPD)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2993.99
Molecular mass(da)37606.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 357
	  		  	1    MSTRRDLPQSPYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACE   60
			  	61   ITLQPIRRYDVDAAILFSDIVVPLRAAGVDLDIVADVGPVIADPVRTAADVAAMKPLDPQ  120
			  	121  AIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGPSRHHAHVKAMMLAEPASWHA  180
			  	181  LMAKLTDLTIAFLVGQIDAGVDAIQVFDSWAGALSPIDYRQYVLPHSARVFAALGEHGVP  240
			  	241  MTHFGVGTAELLGAMSEAVTAGERPGRGAVVGVDWRTPLTDAAARVVPGTALQGNLDPAV  300
			  	301  VLAGWPAVERAARAVVDDGRRAVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 7 to 357  |  Coverage: 98% URO-D Range: 13 to 338  |  Coverage: 91% 1 Range: 4 to 357  |  Coverage: 98% 1
Number of amino acids : 357
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
URO-DPF012087-357
Mtb Structural Proteome models
Model Number1
Model nameRv2678c
Template1J93    APDBCREDO
Template coverage15_331
Template Identity(%)39.7
Model coverage(%)90.8
Normalized DOPE score-0.191

Structure Models from Chopin
Model Number1
Profilec.1.22.1 - 3.20.20.210
Click for model details
zscore71.31
Residue begin4
Residue end357
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2678cGene nameConfidence Score
Rv0510hemC0.999
Rv0510hemC0.999
Rv0512hemB0.999
Rv2677chemY0.998
Rv1485hemZ0.998
Rv2677chemY0.998
Rv2388chemN0.989
Rv2388chemN0.989
Rv0509hemA0.986
Rv0509hemA0.986
Rv0509hemA0.986
Rv2847ccysG0.983
Rv2847ccysG0.983
Rv1876bfrA0.983
Rv0524hemL0.981
Rv1908ckatG0.976
Rv2676cRv2676c0.974
Rv0667rpoB0.973
Rv0667rpoB0.973
Rv0667rpoB0.973
Rv0667rpoB0.973
Rv0667rpoB0.973
Rv0667rpoB0.973
Rv1542cglbN0.972
Rv2470glbO0.97
Rv0511hemD0.969
Rv0511hemD0.969
Rv1848ureA0.966
Rv0527ccdA0.96
Rv2428ahpC0.953
Rv0924cmntH0.952
Rv0006gyrA0.95
Rv0260cRv0260c0.95
Rv0260cRv0260c0.95
Rv0006gyrA0.95
Rv0350dnaK0.942
Rv2193ctaE0.94
Rv3914trxC0.934
Rv2555calaS0.934
Rv2555calaS0.934
Rv2555calaS0.934
Rv1589bioB0.932
Rv1589bioB0.932
Rv2538caroB0.926
Rv2855mtr0.917
Rv2855mtr0.917
Rv2855mtr0.917
Rv0529ccsA0.915
Rv0764ccyp510.915
Rv2788sirR0.913
Rv2788sirR0.913
Rv2788sirR0.913
Rv1699pyrG0.913
Rv1699pyrG0.913
Rv3859cgltB0.911
Rv3859cgltB0.911
Rv3859cgltB0.911
Rv3859cgltB0.911
Rv1471trxB10.91
Rv3250crubB0.909
Rv1436gap0.908
Rv1436gap0.908
Rv0005gyrB0.907
Rv0005gyrB0.907
Rv0005gyrB0.907
Rv0005gyrB0.907
Rv1449ctkt0.906
Rv1449ctkt0.906
Rv1449ctkt0.906
Rv3708casd0.902
Rv1611trpC0.902
Rv3708casd0.902
Rv2870cdxr0.902
Rv2870cdxr0.902
Rv2870cdxr0.902
Rv3043cctaD0.902
Rv1256ccyp1300.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
coproporphyrinogen IIIPubChem0.994660.757
coproporphyrinogen IPubChem0.989660.757
uroporphyrinogen IIIPubChem0.981836.795
protoporphyrinogen IXPubChem0.977568.706
carbon dioxidePubChem0.97244.0095
uroporphyrinogen IPubChem0.965836.795
deuteriumPubChem0.9592.01588
protiumPubChem0.9492.01576
H(+)PubChem0.9492.01588
Fe(III)PubChem0.94855.845
hydrogen peroxidePubChem0.94634.0147
S-adenosyl-L-methioninePubChem0.94399.445
L-methioninePubChem0.939149.211
nitric oxidePubChem0.93931.014
compound IPubChem0.938277.317
porphyrinPubChem0.937310.352
O(2)PubChem0.93715.9994
carbon monoxidePubChem0.92528.0101
hydroxyl radicalsPubChem0.90517.0073
S-adenosyl-methioninePubChem0.9398.437
5'-deoxyadenosinePubChem0.9251.242
acetatePubChem0.89659.044
nitratePubChem0.89562.0049
1,7,7-trimethylbicyclo[2.2.1]heptan-2-onePubChem0.892152.233
protoporphyrinPubChem0.892562.658
heme asPubChem0.891929.018
d-camphorPubChem0.89152.233
pyridine hemochromePubChem0.883774.687
dithionitePubChem0.882128.128
peracetic acidPubChem0.87976.0514
delta-aminolevulinic acidPubChem0.875131.13
cyanidePubChem0.87127.0253
porphobilinogenPubChem0.867226.229
isoniazidPubChem0.866137.139
ascorbic acidPubChem0.862176.124
porphyrinogenPubChem0.854316.4
hemePubChem0.845616.487
nitritePubChem0.844225.181
cysteinatePubChem0.836121.158
hematinPubChem0.83634.503
sodium dithionitePubChem0.829174.107
glycerolPubChem0.82892.0938
iron protoporphyrin IXPubChem0.826616.487
hydroquinonePubChem0.825110.111
heminPubChem0.818651.94
vinylPubChem0.81627.0452
3,3',4,4'-tetrachlorobiphenylPubChem0.812291.988
pyrrolePubChem0.80667.0892
2-mercaptoethanolPubChem0.80378.1334
molecular oxygenPubChem0.80331.9988
propionatePubChem0.874.0785
heme cPubChem0.8858.804
biliverdinPubChem0.799582.646
heme aPubChem0.799852.837
copperPubChem0.79763.546
heme OPubChem0.796838.854
horse heart cytochrome cPubChem0.795884.887
metyraponePubChem0.792226.274
3,3',4,4',5,5'-hexachlorobiphenylPubChem0.792360.878
4Fe-4SPubChem0.7988.9179
thiosulfatePubChem0.788112.128
tetrahydrobiopterinPubChem0.785241.247
semiquinonePubChem0.784626.908
Ap3APubChem0.784756.407
menaquinolPubChem0.784310.43
coproporphyrin IIIPubChem0.782654.709
imidazolePubChem0.78168.0773
heme dPubChem0.779648.486
rhombicPubChem0.773404.973
nitrosylPubChem0.7730.0061
heme a3PubChem0.769858.885
ubiquinol-1PubChem0.768252.306
biliverdin IXalphaPubChem0.768582.646
azidePubChem0.76842.0201
levulinic acidPubChem0.765270.293
ubiquinolPubChem0.765320.423
flavinsPubChem0.764242.233
succinatePubChem0.763118.088
2-heptyl-4-hydroxyquinoline-N-oxidePubChem0.762259.343
sirohemePubChem0.76916.661
verdohemePubChem0.76549.421
glutamate-1-semialdehydePubChem0.76131.13
potassium ferricyanidePubChem0.755329.244
Tn5PubChem0.752270.111
half-cystinePubChem0.752121.158
chlorophyllPubChem0.75895.505
ferrous sulfatePubChem0.748151.908
N,N,N',N'-tetramethyl-p-phenylenediaminePubChem0.747164.247
indolePubChem0.745117.148
hydroxylaminePubChem0.74533.0299
menadiolPubChem0.742174.196
hexachlorobenzenePubChem0.741284.782
L-argininePubChem0.741174.201
precorrin-2PubChem0.74857.792
sulphurPubChem0.7434.0809
3-amino-1,2,4-triazolePubChem0.73784.08
flavin semiquinonePubChem0.735191.011
lipoamidePubChem0.734205.341
singlet oxygenPubChem0.73315.9994
BM-3PubChem0.731219.192
lanosterolPubChem0.73426.717
ammoniaPubChem0.7317.0305
potassium cyanidePubChem0.72965.1157
aldoximePubChem0.72459.0672
p-cresolPubChem0.723108.138
DIETHYL-P-PHENYLENEDIAMINE SULFATEPubChem0.722164.247
prolyl-glycyl-glycinePubChem0.717229.233
o-dianisidinePubChem0.717244.289
acifluorfenPubChem0.716383.639
porphyrin ringPubChem0.716308.336
pyrroloquinoline quinonePubChem0.716330.206
4-phenylimidazolePubChem0.713144.173
hydroxymethylbilanePubChem0.713854.81
glutamatePubChem0.711147.129
econazolePubChem0.708381.684
L-tryptophanPubChem0.708204.225
boratePubChem0.70561.833
tetrathionatePubChem0.704226.272
Mg-protoporphyrin IX monomethyl esterPubChem0.703576.685
sterolPubChem0.7248.404
myristic acidPubChem0.7228.371