SInCRe - Rv0524

Tuberculist information

Gene name	hemL
Protein function	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	614.835
Molecular mass(da)	47515.9
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 462

	  		  	1    MGSTEQATSRVRGAARTSAQLFEAACSVIPGGVNSPVRAFTAVGGTPRFITEAHGCWLID   60
			  	61   ADGNRYVDLVCSWGPMILGHAHPAVVEAVAKAAARGLSFGAPTPAETQLAGEIIGRVAPV  120
			  	121  ERIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHVDALLADAGSGVATLGLCDDP  180
			  	181  QRPASPRSQSSRGLPSSPGVTGAAAADTIVLPYNDIDAVQQTFARFGEQIAAVITEASPG  240
			  	241  NMGVVPPGPGFNAALRAITAEHGALLILDEVMTGFRVSRSGWYGIDPVPADLFAFGKVMS  300
			  	301  GGMPAAAFGGRAEVMQRLAPLGPVYQAGTLSGNPVAVAAGLATLRAADDAVYTALDANAD  360
			  	361  RLAGLLSEALTDAVVPHQISRAGNMLSVFFGETPVTDFASARASQTWRYPAFFHAMLDAG  420
			  	421  VYPPCSAFEAWFVSAALDDAAFGRIANALPAAARAAAQERPA

Known structures in the PDB

No Known structures

Number of amino acids : 462

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Aminotran_3	PF00202	49-392

Mtb Structural Proteome models

Model Number	1
Model name	Rv0524
Template	2GSA APDB CREDO
Template coverage	8_433
Template Identity(%)	45.3
Model coverage(%)	95.7
Normalized DOPE score	-0.089

Structure Models from Chopin

Model Number	1
Profile	c.67.1.4 Click for model details
zscore	28.5
Residue begin	1
Residue end	462

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0524	Gene name	Confidence Score
Rv0512	hemB	0.999
Rv0509	hemA	0.999
Rv0509	hemA	0.999
Rv0509	hemA	0.999
Rv0510	hemC	0.995
Rv0510	hemC	0.995
Rv1485	hemZ	0.983
Rv2678c	hemE	0.981
Rv0511	hemD	0.981
Rv0511	hemD	0.981
Rv2847c	cysG	0.967
Rv2847c	cysG	0.967
Rv2388c	hemN	0.962
Rv2388c	hemN	0.962
Rv2071c	cobM	0.951
Rv2677c	hemY	0.947
Rv2677c	hemY	0.947
Rv2065	cobH	0.937
Rv0527	ccdA	0.927
Rv0525	Rv0525	0.907

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
delta-aminolevulinic acidPubChem	0.978	131.13
glutamate-1-semialdehydePubChem	0.977	131.13
pyridoxamine 5'-phosphatePubChem	0.94	248.173
pyridoxal phosphatePubChem	0.877	247.142
hozPubChem	0.87	132.161
gabaculinePubChem	0.775	139.152
glutamatePubChem	0.74	147.129
glycerolPubChem	0.718	92.0938