Rv0512

Tuberculist information
Gene namehemB
Protein functionProbable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)604.602
Molecular mass(da)34871.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 329
	  		  	1    MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPITSMPGVVQHT   60
			  	61   RDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDPDGILNVALRDLAKDLGEATV  120
			  	121  LMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVAQAESGAHVVGPSGMMDGQVA  180
			  	181  AIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREI  240
			  	241  ELDLDEGADIVMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAA  300
			  	301  VLESLTGIRRAGADIVLTYWAVDAAGWLT

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 6 to 328  |  Coverage: 97% ALAD Range: 5 to 329  |  Coverage: 98% 1 Range: 1 to 329  |  Coverage: 99% 1
Number of amino acids : 329
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ALADPF004906-328
Mtb Structural Proteome models
Model Number1
Model nameRv0512
Template1W5Q    APDBCREDO
Template coverage9_334
Template Identity(%)47.5
Model coverage(%)98.2
Normalized DOPE score-0.607

Structure Models from Chopin
Model Number1
Profilec.1.10.3 - 3.20.20.70
Click for model details
zscore53.66
Residue begin1
Residue end329
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0512Gene nameConfidence Score
Rv0524hemL0.999
Rv0510hemC0.999
Rv0510hemC0.999
Rv2678chemE0.999
Rv0509hemA0.998
Rv0509hemA0.998
Rv0509hemA0.998
Rv1485hemZ0.99
Rv2847ccysG0.974
Rv2847ccysG0.974
Rv2388chemN0.958
Rv2388chemN0.958
Rv0511hemD0.949
Rv0511hemD0.949
Rv2071ccobM0.921
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
porphobilinogenPubChem0.997226.229
zincPubChem0.99665.409
Pb2+PubChem0.994207.2
delta-aminolevulinic acidPubChem0.985131.13
magnesiumPubChem0.96324.305
succinylacetonePubChem0.96158.152
mercuryPubChem0.939200.59
deuteriumPubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
protiumPubChem0.92.01576
levulinic acidPubChem0.863270.293
pyrrolePubChem0.85767.0892
lead acetatePubChem0.824325.288
dimercaptosuccinic acidPubChem0.824182.218
arsenicPubChem0.82374.9216
cadmiumPubChem0.823232.515
meso-2,3-dimercaptosuccinic acidPubChem0.821182.218
copperPubChem0.81863.546
ethylenediaminetetraacetic acidPubChem0.816292.243
4-keto-5-amino-hexanoic acidPubChem0.809147.172
diphenyl ditelluridePubChem0.807409.408
hydron sulfatePubChem0.798196.157
sulfatePubChem0.79896.0626
unithiolPubChem0.797188.289
5-fluoro-4-oxo-pentanoic acidPubChem0.795134.106
4,7-diketosebacic acidPubChem0.787230.215
4-ketosebacic acidPubChem0.787216.231
hemePubChem0.786616.487
glycerolPubChem0.78592.0938
selenomethioninePubChem0.785196.106
SeMetPubChem0.785196.106
valeratePubChem0.785102.132
aluminumPubChem0.7826.9815
2-mercaptoethanolPubChem0.77978.1334
poly(dl-lactide-co-caprolactone)PubChem0.768118.131
2,3-dimercaptopropanolPubChem0.765124.225
trimethyl lead chloridePubChem0.752287.757
mercuric chloridePubChem0.746271.496
porphyrinPubChem0.728310.352
chlorophyllPubChem0.723895.505
uroporphyrinogen IPubChem0.72836.795
chloridePubChem0.70635.453
Na(+)PubChem0.722.9898