Rv0509

Tuberculist information
Gene namehemA
Protein functionProbable glutamyl-tRNA reductase HemA (GLUTR)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)600.441
Molecular mass(da)49329.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 468
	  		  	1    VSVLLFGVSHRSAPVVVLEQLSIDESDQVKIIDRVLASPLVTEAMVLSTCNRVEVYAVVD   60
			  	61   AFHGGLSVIGQVLAEHSGMSMGELTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQ  120
			  	121  VRRAYAVAESNRTVGRVLHELAQRALSVGKRVHSETAIDAAGASVVSVALGMAERKLGSL  180
			  	181  AGTTAVVIGAGAMGALSAVHLTRAGVGHIQVLNRSLSRAQRLARRIRESGVPAEALALDR  240
			  	241  LANVLADADVVVSCTGAVRPVVSLADVHHALAAARRDEATRPLVICDLGMPRDVDPAVAR  300
			  	301  LPCVWVVDVDSVQHEPSAHAAAADVEAARHIVAAEVASYLVGQRMAEVTPTVTALRQRAA  360
			  	361  EVVEAELLRLDNRLPGLQSVQREEVARTVRRVVDKLLHAPTVRIKQLASAPGGDSYAEAL  420
			  	421  RELFELDQTAVDAVATAGELPVVPSGFDAESRRGGGDMQSSPKRSPSN

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 6 to 157  |  Coverage: 32% GlutR_N Range: 171 to 315  |  Coverage: 30% Shikimate_DH Range: 326 to 427  |  Coverage: 21% GlutR_dimer Range: 7 to 440  |  Coverage: 92% 1 Range: 1 to 428  |  Coverage: 91% 1 Range: 1 to 158  |  Coverage: 33% 2 Range: 171 to 315  |  Coverage: 30% 3 Range: 326 to 427  |  Coverage: 21% 4
Number of amino acids : 468
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GlutR_NPF052016-157
Shikimate_DHPF01488171-315
GlutR_dimerPF00745326-427
Mtb Structural Proteome models
Model Number1
Model nameRv0509
Template1GPJ    APDBCREDO
Template coverage8_402
Template Identity(%)36.4
Model coverage(%)92.5
Normalized DOPE score0.619

Structure Models from Chopin
Model Number1
Profilea.151.1.1, c.2.1.7, d.58.39.1 - 1.10.1200.70, 3.40.50.720
Click for model details
zscore56.18
Residue begin1
Residue end428
Model Number2
Profiled.58.39.1
Click for model details
zscore39.38
Residue begin1
Residue end158
Model Number3
Profilec.2.1.13
Click for model details
zscore13.03
Residue begin171
Residue end315
Model Number4
Profilea.151.1.1
Click for model details
zscore12.94
Residue begin326
Residue end427
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0509Gene nameConfidence Score
Rv0524hemL0.999
Rv0510hemC0.999
Rv0510hemC0.999
Rv0512hemB0.998
Rv0511hemD0.995
Rv0511hemD0.995
Rv2847ccysG0.988
Rv2847ccysG0.988
Rv2678chemE0.986
Rv1485hemZ0.984
Rv2992cgltS0.983
Rv2677chemY0.976
Rv2677chemY0.976
Rv2388chemN0.965
Rv2388chemN0.965
Rv2071ccobM0.954
Rv1299prfA0.938
Rv1299prfA0.938
Rv2065cobH0.929
Rv0255ccobQ10.926
Rv0255ccobQ10.926
Rv1300hemK0.925
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glutamate-1-semialdehydePubChem0.978131.13
glutamatePubChem0.933147.129
glutamol-AMPPubChem0.822462.352
delta-aminolevulinic acidPubChem0.789131.13