Rv0255c

Tuberculist information
Gene namecobQ1
Protein functionProbable cobyric acid synthase CobQ1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)306.374
Molecular mass(da)52134.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 494
	  		  	1    MSGLLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFKAQNMSNNSMVCRGPDGTGVEIGR   60
			  	61   AQWVQALAARTTPEAAMNPVLLKPASDHRSHVVLMGKPWGEVASSSWCAGRRALAEAACR  120
			  	121  AFDALAARYDVVVAEGAGSPAEINLRAGDYVNMGLARHAGLPTIVVGDIDRGGVFAAFLG  180
			  	181  TVALLAAEDQALVAGFVVNKFRGDSDLLAPGLRDLERVTGRRVYGTLPWHPDLWLDSEDA  240
			  	241  LDLQGRRAAGTGARRVAVVRLPRISNFTDVDALGLEPDLDVVFASDPRALDDADLIVLPG  300
			  	301  TRATIADLAWLRARDLDRALLVHVAAGKPLLGICGGFQMLGRVIRDPYGIEGPGGQVTEV  360
			  	361  EGLGLLDVETAFSPHKVLRLPRGEGLGVPASGYEIHHGRITRGDTAEEFLGGARDGPVFG  420
			  	421  TMWHGSLEGDALREAFLRETLGLAPSGSCFLAARERRLDLLGDLVERHLDVDALLNLARH  480
			  	481  GCPPTLPFLAPGAP

Known structures in the PDB
No Known structures
1 50 99 148 197 246 295 344 393 442 491 Range: 4 to 243  |  Coverage: 48% CbiA Range: 286 to 432  |  Coverage: 29% GATase_3 Range: 268 to 444  |  Coverage: 35% 1 Range: 286 to 432  |  Coverage: 29% 1 Range: 225 to 432  |  Coverage: 41% 2
Number of amino acids : 494
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CbiAPF016564-243
GATase_3PF07685286-432
Mtb Structural Proteome models
Model Number1
Model nameRv0255c
Template1R9G    APDBCREDO
Template coverage14_191
Template Identity(%)20.9
Model coverage(%)35.6
Normalized DOPE score-0.362

Structure Models from Chopin
Model Number1
Profilec.23.16.1 - 3.40.50.880
Click for model details
zscore12.11
Residue begin286
Residue end432
Model Number2
Profilec.23.16.4 - 3.40.50.880
Click for model details
zscore8.01
Residue begin225
Residue end432
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0255cGene nameConfidence Score
Rv2236ccobD0.998
Rv0254ccobU0.998
Rv2849ccobO0.996
Rv2848ccobB0.994
Rv2848ccobB0.994
Rv2207cobT0.982
Rv2066cobI0.976
Rv2208cobS0.97
Rv2231ccobC0.967
Rv2071ccobM0.965
Rv2065cobH0.955
Rv2062ccobN0.955
Rv2070ccobK0.936
Rv2847ccysG0.929
Rv2847ccysG0.929
Rv0509hemA0.926
Rv0509hemA0.926
Rv0509hemA0.926
Rv0306Rv03060.912
Rv2072ccobL0.907
Rv2072ccobL0.907
Rv0646clipG0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosylcobyric acidPubChem0.9681183.23
phosphatePubChem0.92596.9872
adenosyl-cobinamide-phosphatePubChem0.91320.3
CPD-694PubChem0.9936.932
hydroxyl radicalsPubChem0.917.0073
adenosyl-cobyratePubChem0.91182.22
adenosine diphosphatePubChem0.9427.201
cob(II)yrinic acid a,c-diamidePubChem0.9936.932
glutaminPubChem0.9146.145
glutamatePubChem0.9147.129
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
CPD-690PubChem0.91182.13
triphosphoric acidPubChem0.9257.955
C06509PubChem0.91320.3
(R)-1-amino-2-propanol O-2-phosphatePubChem0.9155.09
adenosine triphosphatePubChem0.9507.181
C06506PubChem0.91187.17
H(+)PubChem0.92.01588
polyglutaminePubChem0.9146.145