Rv0254c

Tuberculist information
Gene namecobU
Protein functionProbable bifunctional cobalamin biosynthesis protein CobU: cobinamide kinase + cobinamide phosphate guanylyltransferase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)305.825
Molecular mass(da)18109.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 174
	  		  	1    VRILVTGGVRSGKSTHAEALLGDAADVVYVAPGRPAAGSDPDWDARVALHRARRPPTWLT   60
			  	61   VETADVATALSEARSPVLVDCLGTWLTAIMDGEALWSAATADVYAVLEARLDGLCAALTG  120
			  	121  LPTAIVVTNEVGLGVVPSHSSGVLFRDLLGTINRRVAAVCDEVHLVIAGRVLKL

Known structures in the PDB
No Known structures
1 18 35 52 69 86 103 120 137 154 171 Range: 3 to 174  |  Coverage: 98% CobU Range: 2 to 174  |  Coverage: 98% 1 Range: 1 to 168  |  Coverage: 95% 1
Number of amino acids : 174
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CobUPF022833-174
Mtb Structural Proteome models
Model Number1
Model nameRv0254c
Template1C9K    APDBCREDO
Template coverage1_179
Template Identity(%)37.9
Model coverage(%)98.9
Normalized DOPE score-0.305

Structure Models from Chopin
Model Number1
Profilec.37.1.24
Click for model details
zscore4.31
Residue begin1
Residue end168
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0254cGene nameConfidence Score
Rv2208cobS0.999
Rv0255ccobQ10.998
Rv0255ccobQ10.998
Rv2236ccobD0.998
Rv2207cobT0.997
Rv2849ccobO0.995
Rv2848ccobB0.974
Rv2848ccobB0.974
Rv2065cobH0.946
Rv2071ccobM0.941
Rv2066cobI0.938
Rv2062ccobN0.926
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
pyrophosphatePubChem0.971177.975
adenosylcobinamidePubChem0.9531240.32
adenosylcobinamide-GDPPubChem0.9521665.51
adenosyl-cobinamide-phosphatePubChem0.951320.3
adenosyl-cobinamidePubChem0.951240.32
cobinamidePubChem0.949990.087
cobyrinic acid a,c-diamidePubChem0.9990.087
deuteriumPubChem0.92.01588
2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol; cobalt(3+); 3-[(1R,2S,3S,5Z,7S,8S,10Z,13S,15Z,17PubChem0.91240.32
adenosine diphosphatePubChem0.9427.201
H(+)PubChem0.92.01588
guanosine triphosphatePubChem0.9523.18
protiumPubChem0.92.01576
triphosphoric acidPubChem0.9257.955
CHEBI:2479PubChem0.91665.51
C06509PubChem0.91320.3
adenosine triphosphatePubChem0.9507.181
phosphatePubChem0.74196.9872