Rv2236c

Tuberculist information
Gene namecobD
Protein functionProbable cobalamin biosynthesis transmembrane protein CobD
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2508.43
Molecular mass(da)32944.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 313
	  		  	1    VFASTWQTRAVGVLIGCLLDVVFGDPKRGHPVALFGRAAAKLEQITYRDGRVAGAVHVGL   60
			  	61   LVGAVGLLGAALQRLPGRSWPVAATATATWAALGGTSLARTGRQISDLLERDDVEAARRL  120
			  	121  LPSLCGRDPAQLGGPGLTRAALESVAENTADAQVVPLLWAASSGVPAVLGYRAINTLDSM  180
			  	181  IGYRSPRYLRFGWAAARLDDWANYVGARATAVLVVICAPVVGGSPRGAVRAWRRDAARHP  240
			  	241  SPNAGVVEAAFAGALDVRLGGPTRYHHELQIRPTLGDGRSPKVADLRRAVVLSRVVQAGA  300
			  	301  AVLAVMLVYRRRP

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 10 to 297  |  Coverage: 91% CobD_Cbib
Number of amino acids : 313
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CobD_CbibPF0318610-297
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2236cGene nameConfidence Score
Rv0254ccobU0.998
Rv0255ccobQ10.998
Rv0255ccobQ10.998
Rv2849ccobO0.995
Rv2848ccobB0.988
Rv2848ccobB0.988
Rv2207cobT0.978
Rv2071ccobM0.974
Rv2208cobS0.967
Rv2065cobH0.959
Rv2231ccobC0.94
Rv2066cobI0.938
Rv2062ccobN0.934
Rv2070ccobK0.93
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosylcobyric acidPubChem0.9671183.23
adenosylcobinamidePubChem0.9651240.32
adenosyl-cobinamide-phosphatePubChem0.9461320.3
C06509PubChem0.91320.3
adenosyl-cobinamidePubChem0.91240.32