Rv2066

Tuberculist information
Gene namecobI
Protein functionProbable bifunctional protein, CobI-COBJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2323.18
Molecular mass(da)53911
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 508
	  		  	1    MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE   60
			  	61   EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL  120
			  	121  HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV  180
			  	181  VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR  240
			  	241  RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT  300
			  	301  DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV  360
			  	361  ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE  420
			  	421  LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV  480
			  	481  DSQDRVFTPRRYPEAGRATATKSSRHSD

Known structures in the PDB
No Known structures
1 51 101 151 201 251 301 351 401 451 501 Range: 6 to 224  |  Coverage: 42% TP_methylase Range: 248 to 458  |  Coverage: 41% TP_methylase Range: 1 to 480  |  Coverage: 94% 1 Range: 1 to 132  |  Coverage: 25% 1 Range: 248 to 379  |  Coverage: 25% 2 Range: 1 to 219  |  Coverage: 42% 3 Range: 1 to 219  |  Coverage: 42% 4 Range: 248 to 466  |  Coverage: 42% 5
Number of amino acids : 508
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TP_methylasePF005906-224
TP_methylasePF00590248-458
Mtb Structural Proteome models
Model Number1
Model nameRv2066
Template1PJQ    APDBCREDO
Template coverage10_456
Template Identity(%)16.9
Model coverage(%)94.3
Normalized DOPE score1.436

Structure Models from Chopin
Model Number1
Profile3.40.1010.10
Click for model details
zscore11.93
Residue begin1
Residue end132
Model Number2
Profile3.40.1010.10
Click for model details
zscore11.93
Residue begin248
Residue end379
Model Number3
Profilec.2.1.11, c.90.1.1, e.37.1.1 - 1.10.8.210, 3.30.160.110, 3.30.950.10, 3.40.1010.10, 3.40.50.720
Click for model details
zscore9.72
Residue begin1
Residue end219
Model Number4
Profilec.90.1.1
Click for model details
zscore9.07
Residue begin1
Residue end219
Model Number5
Profilec.90.1.1
Click for model details
zscore9.07
Residue begin248
Residue end466
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2066Gene nameConfidence Score
Rv2065cobH0.999
Rv2071ccobM0.999
Rv2064cobG0.998
Rv2070ccobK0.994
Rv2847ccysG0.991
Rv2847ccysG0.991
Rv2848ccobB0.983
Rv2848ccobB0.983
Rv2072ccobL0.98
Rv2072ccobL0.98
Rv0255ccobQ10.976
Rv0255ccobQ10.976
Rv2062ccobN0.96
Rv0511hemD0.94
Rv0511hemD0.94
Rv0254ccobU0.938
Rv2236ccobD0.938
Rv2849ccobO0.923
Rv2207cobT0.917
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
precorrin-2PubChem0.965857.792
precorrin-3APubChem0.959871.819
S-adenosyl-L-methioninePubChem0.949399.445
precorrin-3BPubChem0.944887.818
S-adenosylhomocysteinePubChem0.943384.411
precorrin-4PubChem0.942908.9
precorrin-5PubChem0.941922.927
molecular oxygenPubChem0.90931.9988
NAD+PubChem0.908663.425
H(+)PubChem0.92.01588
C06406PubChem0.9894.874
dihydrosirohydrochlorinPubChem0.9864.848
precorrin 4PubChem0.9908.9
cobalt-precorrin-4PubChem0.9949.818
protiumPubChem0.92.01576
CPD-651PubChem0.9900.837
hydroxyl radicalsPubChem0.917.0073
C05772PubChem0.9878.874
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
precorrin-1PubChem0.9850.821
Precorrin 5PubChem0.9922.927
deuteriumPubChem0.92.01588
S-adenosyl-methioninePubChem0.9398.437
reduced nicotinamide adenine dinucleotidePubChem0.9665.441