Rv2849c

Tuberculist information
Gene namecobO
Protein functionProbable cob(I)alamin adenosyltransferase CobO (corrinoid adenosyltransferase) (corrinoid adotransferase activity)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3157.52
Molecular mass(da)22810
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 207
	  		  	1    MPQGNPLAVPNDGLTTRARRNMPILAVHTGEGKGKSTAAFGMALRAWNAGLDIAVFQFVK   60
			  	61   SAKWKVGEEAAFRQLGRLHDQHGIGGAVEWHKMGAGWSWTRTSRKAGTDVDRAAAAADGW  120
			  	121  AEIALRLATQRHDFYLLDEFTYPLKWGWLDVDEVVDVLRARPGHQHVVITGRDAPQRLVA  180
			  	181  AADLVTEMTKVKHPMDAGRKGQKGIEW

Known structures in the PDB
No Known structures
1 21 41 61 81 101 121 141 161 181 201 Range: 20 to 207  |  Coverage: 90% CobA_CobO_BtuR Range: 21 to 193  |  Coverage: 83% 1 Range: 16 to 190  |  Coverage: 84% 1
Number of amino acids : 207
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CobA_CobO_BtuRPF0257220-207
Mtb Structural Proteome models
Model Number1
Model nameRv2849c
Template1G5T    APDBCREDO
Template coverage27_182
Template Identity(%)41.7
Model coverage(%)83.1
Normalized DOPE score-0.414

Structure Models from Chopin
Model Number1
Profilec.37.1.24
Click for model details
zscore6.31
Residue begin16
Residue end190
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2849cGene nameConfidence Score
Rv0255ccobQ10.996
Rv0255ccobQ10.996
Rv0254ccobU0.995
Rv2236ccobD0.995
Rv2848ccobB0.993
Rv2848ccobB0.993
Rv2062ccobN0.955
Rv2207cobT0.949
Rv2850cRv2850c0.939
Rv2850cRv2850c0.939
Rv2071ccobM0.938
Rv2208cobS0.928
Rv2066cobI0.923
Rv2065cobH0.912
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine triphosphatePubChem0.966507.181
adenosylcobyric acidPubChem0.9451183.23
adenosylcobinamidePubChem0.9421240.32
adenosine diphosphatePubChem0.907427.201
phosphatePubChem0.90696.9872
CPD-690PubChem0.91182.13
deuteriumPubChem0.92.01588
adenosyl-cobinamidePubChem0.91240.32
triphosphoric acidPubChem0.9257.955
glutaminPubChem0.9146.145
reduced flavin mononucleotidePubChem0.9458.36
flavin mononucleotidePubChem0.9456.344
C06506PubChem0.91187.17
CPD-694PubChem0.9936.932
polyglutaminePubChem0.9146.145
adenosyl-cobyratePubChem0.91182.22
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
glutamatePubChem0.9147.129
cob(II)yrinic acid a,c-diamidePubChem0.9936.932
protiumPubChem0.92.01576
FMNH2PubChem0.9458.36