Rv2062c

Tuberculist information
Gene namecobN
Protein functionCobalamin biosynthesis protein CobN
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2317.17
Molecular mass(da)129178
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1194
	  		  	1    VPEPTVLLLSTSDTDLISARSSGKNYRWANPSRLSDLELTDLLAEASIVVIRILGGYRAW   60
			  	61   QSGIDTVIAGGVPAVLVSGEQAADAELTDRSTVAAGTALQAHIYLAHGGVDNLRELHAFL  120
			  	121  CDTVLMTGFGFTPPVATPTWGVLERPDAGKTGPTIAVLYYRAQHLAGNTGYVEALCRAIE  180
			  	181  DAGGRPLPLYCASLRTAEPRLLERLGGADAMVVTVLAAGGVKPAAASAGGDDDSWNVEHL  240
			  	241  AALDIPILQGLCLTSPRDQWCANDDGLSPLDVASQVAVPEFDGRIITVPFSFKEIDDDGL  300
			  	301  ISYVADPERCARVAGLAVRHARLRQVAPADKRVALVFSAYPTKHARIGNAVGLDTPASAV  360
			  	361  ALLQAMRQRGYRVGDLPGVESNDGDALIHALIECGGHDPDWLTEGQLAGNPIRVSAKEYR  420
			  	421  DWFATLPAELTDVVTAYWGPPPGELFVDRSHDPDGEIVIAALRAGNLVLMVQPPRGFGEN  480
			  	481  PVAIYHDPDLPPSHHYLAAYRWLDTGFSNGFGAHAVVHLGKHGNLEWLPGKTLGMSASCG  540
			  	541  PDAALGDLPLIYPFLVNDPGEGTQAKRRAHAVLVDHLIPPMARAETYGDIARLEQLLDEH  600
			  	601  ASVAALDPGKLPAIRQQIWTLIRAAKMDHDLGLTERPEEDSFDDMLLHVDGWLCEIKDVQ  660
			  	661  IRDGLHILGQNPTGEQELDLVLAILRARQLFGGAHAIPGLRQALGLAEDGTDERATVDQT  720
			  	721  EAKARELVAALQATGWDPSAADRLTGNADAAAVLRFAATEVIPRLAGTATEIEQVLRALD  780
			  	781  GRFIPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRLAWEAGVALADSLLARYRDEHGR  840
			  	841  WPRSVGLSVWGTSAMRTAGDDIAEVLALLGVRPVWDDASRRVIDLAPMQPAELGRPRIDV  900
			  	901  TVRISGFFRDAFPHVVTMLDDAVRLVADLDEAAEDNYVRAHAQADLAHHGDQRRATTRIF  960
			  	961  GSKPGTYGAGLLQLIDSRSWRDDADLAQVYTAWGGFAYGRDLDGREAIDDMNRQYRRIAV 1020
			  	1021 AAKNTDTREHDIADSDDYFQYHGGMVATVRALTGQAPAAYIGDNTRPDAIRTRTLSEETT 1080
			  	1081 RVFRARVVNPRWMAAMRRHGYKGAFEMAATVDYLFGYDATAGVMADWMYEQLTQRYVLDA 1140
			  	1141 QNRTFMTESNPWALHGMAERLLEAAGRGLWAQPAPETLDGLRQVLLETEGDLEA

Known structures in the PDB
No Known structures
1 120 239 358 477 596 715 834 953 1072 1191 Range: 101 to 1179  |  Coverage: 90% CobN-Mg_chel
Number of amino acids : 1194
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CobN-Mg_chelPF02514101-1179
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2062cGene nameConfidence Score
Rv2848ccobB0.995
Rv2848ccobB0.995
Rv2070ccobK0.992
Rv2850cRv2850c0.989
Rv2850cRv2850c0.989
Rv2064cobG0.976
Rv2065cobH0.968
Rv2066cobI0.96
Rv0255ccobQ10.955
Rv2849ccobO0.955
Rv2071ccobM0.955
Rv0255ccobQ10.955
Rv0306Rv03060.953
Rv2207cobT0.949
Rv2236ccobD0.934
Rv0254ccobU0.926
Rv2208cobS0.915
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
hydrogenobyrinic acid a,c-diamidePubChem0.968879.007
cob(II)yrinic acid a,c-diamidePubChem0.949936.932