SInCRe - Rv2207

Tuberculist information

Gene name	cobT
Protein function	Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	2471.41
Molecular mass(da)	36411.3
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 361

	  		  	1    MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCPPRQFERARVV   60
			  	61   VFAGDHGVARSGVSAYPPEVTAQMVANIDAGGAAINALADVAGATVRVADLAVDADPLSE  120
			  	121  RIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAA  180
			  	181  AVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADL  240
			  	241  AAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEPGHGLALAAL  300
			  	301  GLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEAGVSTRSVDGVDRTAPPAVS  360
			  	361  P

Known structures in the PDB

No Known structures

Number of amino acids : 361

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
DBI_PRT	PF02277	4-343

Mtb Structural Proteome models

Model Number	1
Model name	Rv2207
Template	1WX1 APDB CREDO
Template coverage	2_333
Template Identity(%)	49.5
Model coverage(%)	92.0
Normalized DOPE score	-0.465

Structure Models from Chopin

Model Number	1
Profile	c.39.1.1 Click for model details
zscore	50.36
Residue begin	1
Residue end	349

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2207	Gene name	Confidence Score
Rv2208	cobS	0.998
Rv0254c	cobU	0.997
Rv2848c	cobB	0.989
Rv2848c	cobB	0.989
Rv2228c	Rv2228c	0.983
Rv2228c	Rv2228c	0.983
Rv0255c	cobQ1	0.982
Rv0255c	cobQ1	0.982
Rv2236c	cobD	0.978
Rv0306	Rv0306	0.976
Rv2849c	cobO	0.949
Rv2062c	cobN	0.949
Rv2071c	cobM	0.939
Rv2065	cobH	0.936
Rv2066	cobI	0.917
Rv2070c	cobK	0.901

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
alpha-ribazole 5'-phosphatePubChem	0.989	358.284
nicotinic acid mononucleotidePubChem	0.989	336.212
5,6-dimethylbenzimidazolePubChem	0.989	146.189
nicotinate mononucleotidePubChem	0.983	335.204
nicotinic acidPubChem	0.969	122.101
alpha-ribazolePubChem	0.968	278.304
phosphatePubChem	0.967	96.9872
reduced nicotinamide adenine dinucleotidePubChem	0.9	665.441
H(+)PubChem	0.9	2.01588
erythrose 4-phosphatePubChem	0.9	200.084
molecular oxygenPubChem	0.9	31.9988
reduced flavin mononucleotidePubChem	0.9	458.36
deuteriumPubChem	0.9	2.01588
DMB-ribose-5'-PPubChem	0.9	356.268
NAD+PubChem	0.9	663.425
D-erythrose 4-phosphatePubChem	0.9	200.084
dihydronicotinamide formycin dinucleotidePubChem	0.9	665.441
hydroxyl radicalsPubChem	0.9	17.0073
(2S,5R)-2-(5,6-dimethylbenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diolPubChem	0.9	278.304
FMNH2PubChem	0.9	458.36
protiumPubChem	0.9	2.01576
4,5-dimethyl-1,2-phenylenediaminePubChem	0.827	136.194
5-methoxybenzimidazolePubChem	0.819	148.162
5MbPubChem	0.814	132.163
2,5-xylidinePubChem	0.805	121.18
2AcPubChem	0.801	123.152
2MPPubChem	0.798	122.164
adeninePubChem	0.785	135.127
34aPubChem	0.784	121.18
4-methylcatecholPubChem	0.782	124.137
p-cresolPubChem	0.758	108.138
benzimidazolePubChem	0.72	118.136
indolePubChem	0.718	117.148
phenolPubChem	0.704	94.1112