Rv2071c

Tuberculist information
Gene namecobM
Protein functionPrecorrin-3 methylase CobM (precorrin-4 C11-methyltransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2328.22
Molecular mass(da)26420.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 251
	  		  	1    MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE   60
			  	61   QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL  120
			  	121  KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG  180
			  	181  GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL  240
			  	241  YSVARHGRYAQ

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 2 to 210  |  Coverage: 82% TP_methylase Range: 1 to 227  |  Coverage: 90% 1 Range: 1 to 251  |  Coverage: 99% 1
Number of amino acids : 251
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TP_methylasePF005902-210
Mtb Structural Proteome models
Model Number1
Model nameRv2071c
Template1CBF    APDBCREDO
Template coverage21_246
Template Identity(%)42.0
Model coverage(%)90.0
Normalized DOPE score-0.677

Structure Models from Chopin
Model Number1
Profilec.90.1.1
Click for model details
zscore26.86
Residue begin1
Residue end251
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2071cGene nameConfidence Score
Rv2066cobI0.999
Rv2070ccobK0.999
Rv2072ccobL0.996
Rv2072ccobL0.996
Rv2065cobH0.993
Rv2848ccobB0.984
Rv2848ccobB0.984
Rv2236ccobD0.974
Rv0255ccobQ10.965
Rv0255ccobQ10.965
Rv2062ccobN0.955
Rv0509hemA0.954
Rv0509hemA0.954
Rv0509hemA0.954
Rv0524hemL0.951
Rv0254ccobU0.941
Rv2207cobT0.939
Rv2849ccobO0.938
Rv0510hemC0.923
Rv0510hemC0.923
Rv0512hemB0.921
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
S-adenosyl-L-methioninePubChem0.958399.445
precorrin-3BPubChem0.947887.818
precorrin-5PubChem0.947922.927
precorrin-4PubChem0.946908.9
precorrin-6xPubChem0.946887.861
cobalt-precorrin-4PubChem0.945949.818
S-adenosylhomocysteinePubChem0.928384.411
acetatePubChem0.9159.044
S-adenosyl-methioninePubChem0.902398.437
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
CPD-651PubChem0.9900.837
H(+)PubChem0.92.01588
Precorrin 5PubChem0.9922.927
deuteriumPubChem0.92.01588
Precorrin 6aPubChem0.9894.917
C06406PubChem0.9894.874
precorrin 4PubChem0.9908.9
precorrin-2PubChem0.716857.792
sirohydrochlorinPubChem0.704862.832