Rv0510

Tuberculist information
Gene namehemC
Protein functionProbable porphobilinogen deaminase HemC (PBG) (hydroxymethylbilane synthase) (HMBS) (pre-uroporphyrinogen synthase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)601.857
Molecular mass(da)31906.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 309
	  		  	1    VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE   60
			  	61   AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS  120
			  	121  SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE  180
			  	181  PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA  240
			  	241  IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA  300
			  	301  RELMWGVRH

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 1 to 209  |  Coverage: 67% Porphobil_deam Range: 217 to 297  |  Coverage: 25% Porphobil_deamC Range: 1 to 309  |  Coverage: 99% 1 Range: 212 to 308  |  Coverage: 31% 1
Number of amino acids : 309
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Porphobil_deamPF013791-209
Porphobil_deamCPF03900217-297
Mtb Structural Proteome models
Model Number1
Model nameRv0510
Template1GTK    APDBCREDO
Template coverage5_308
Template Identity(%)44.6
Model coverage(%)99.7
Normalized DOPE score-0.1

Structure Models from Chopin
Model Number1
Profiled.50.2.1
Click for model details
zscore22.57
Residue begin212
Residue end308
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0510Gene nameConfidence Score
Rv0512hemB0.999
Rv0509hemA0.999
Rv0509hemA0.999
Rv0509hemA0.999
Rv2678chemE0.999
Rv0511hemD0.998
Rv0511hemD0.998
Rv0524hemL0.995
Rv2847ccysG0.987
Rv2847ccysG0.987
Rv1485hemZ0.981
Rv0260cRv0260c0.929
Rv0260cRv0260c0.929
Rv2071ccobM0.923
Rv2388chemN0.923
Rv2388chemN0.923
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
porphobilinogenPubChem0.991226.229
hydroxymethylbilanePubChem0.984854.81
deuteriumPubChem0.9162.01588
ammoniaPubChem0.91517.0305
H(+)PubChem0.9062.01588
hydroxyl radicalsPubChem0.90217.0073
CHEBI:111705PubChem0.9846.746
protiumPubChem0.92.01576
dipyrromethanePubChem0.9146.189
delta-aminolevulinic acidPubChem0.889131.13
uroporphyrinogen IIIPubChem0.88836.795
hemePubChem0.871616.487
sirohemePubChem0.86916.661
heminPubChem0.822651.94
3-[5-[[(2S)-3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-2H-pyrrol-2-yl]methyl]-4-(carboxymethyl)-2PubChem0.778420.413
DB04517PubChem0.778420.413
dipyrromethane cofactorPubChem0.764420.413
sirohydrochlorinPubChem0.746862.832
phenylhydrazinePubChem0.729108.141
porphyrinPubChem0.724310.352
uroporphyrinogen IPubChem0.721836.795
sulfatePubChem0.71796.0626
protoporphyrinPubChem0.704562.658