Rv2847c

Tuberculist information
Gene namecysG
Protein functionPossible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3154.65
Molecular mass(da)41938.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 405
	  		  	1    VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS   60
			  	61   VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG  120
			  	121  LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR  180
			  	181  RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV  240
			  	241  VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV  300
			  	301  SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT  360
			  	361  AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 8 to 114  |  Coverage: 26% NAD_binding_7 Range: 161 to 374  |  Coverage: 52% TP_methylase Range: 3 to 405  |  Coverage: 99% 1 Range: 3 to 405  |  Coverage: 99% 1 Range: 161 to 374  |  Coverage: 52% 2 Range: 154 to 405  |  Coverage: 61% 3 Range: 8 to 111  |  Coverage: 25% 4 Range: 155 to 276  |  Coverage: 29% 5 Range: 112 to 156  |  Coverage: 10% 6
Number of amino acids : 405
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAD_binding_7PF132418-114
TP_methylasePF00590161-374
Mtb Structural Proteome models
Model Number1
Model nameRv2847c
Template1PJQ    APDBCREDO
Template coverage1_456
Template Identity(%)33.0
Model coverage(%)99.0
Normalized DOPE score0.487

Structure Models from Chopin
Model Number1
Profilec.2.1.11, c.90.1.1, e.37.1.1 - 1.10.8.210, 3.30.160.110, 3.30.950.10, 3.40.1010.10, 3.40.50.720
Click for model details
zscore66.09
Residue begin3
Residue end405
Model Number2
Profilec.90.1.1
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zscore27.14
Residue begin161
Residue end374
Model Number3
Profile3.30.950.10, 3.40.1010.10
Click for model details
zscore24.83
Residue begin154
Residue end405
Model Number4
Profilec.2.1.11
Click for model details
zscore22.22
Residue begin8
Residue end111
Model Number5
Profile3.40.1010.10
Click for model details
zscore11.95
Residue begin155
Residue end276
Model Number6
Profile3.30.160.110
Click for model details
zscore4.79
Residue begin112
Residue end156
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2847cGene nameConfidence Score
Rv2392cysH0.996
Rv2066cobI0.991
Rv0509hemA0.988
Rv0509hemA0.988
Rv0509hemA0.988
Rv0510hemC0.987
Rv0510hemC0.987
Rv2678chemE0.983
Rv0512hemB0.974
Rv2391sirA0.972
Rv2391sirA0.972
Rv1285cysD0.97
Rv0260cRv0260c0.968
Rv0260cRv0260c0.968
Rv0524hemL0.967
Rv1286cysN0.964
Rv1286cysN0.964
Rv1286cysN0.964
Rv2848ccobB0.959
Rv2848ccobB0.959
Rv0252nirB0.956
Rv0252nirB0.956
Rv0252nirB0.956
Rv0252nirB0.956
Rv0252nirB0.956
Rv0511hemD0.951
Rv0511hemD0.951
Rv2393che10.946
Rv1485hemZ0.934
Rv0255ccobQ10.929
Rv0255ccobQ10.929
Rv2065cobH0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
uroporphyrinogen IIIPubChem0.979836.795
S-adenosyl-L-methioninePubChem0.975399.445
precorrin-2PubChem0.972857.792
S-adenosylhomocysteinePubChem0.97384.411
sirohydrochlorinPubChem0.969862.832
dihydrosirohydrochlorinPubChem0.959864.848
precorrin-1PubChem0.943850.821
S-adenosyl-methioninePubChem0.911398.437
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
sirohemePubChem0.818916.661
nitritePubChem0.702225.181