Rv2392

Tuberculist information
Gene namecysH
Protein functionProbable 3'-phosphoadenosine 5'-phosphosulfate reductase CysH (PAPS reductase, thioredoxin DEP.) (padops reductase) (3'- phosphoadenylylsulfate reductase) (PAPS sulfotransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2686.37
Molecular mass(da)27422.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 254
	  		  	1    MSGETTRLTEPQLRELAARGAAELDGATATDMLRWTDETFGDIGGAGGGVSGHRGWTTCN   60
			  	61   YVVASNMADAVLVDLAAKVRPGVPVIFLDTGYHFVETIGTRDAIESVYDVRVLNVTPEHT  120
			  	121  VAEQDELLGKDLFARNPHECCRLRKVVPLGKTLRGYSAWVTGLRRVDAPTRANAPLVSFD  180
			  	181  ETFKLVKVNPLAAWTDQDVQEYIADNDVLVNPLVREGYPSIGCAPCTAKPAEGADPRSGR  240
			  	241  WQGLAKTECGLHAS

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 58 to 229  |  Coverage: 67% PAPS_reduct Range: 17 to 225  |  Coverage: 81% 1 Range: 1 to 225  |  Coverage: 88% 1
Number of amino acids : 254
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PAPS_reductPF0150758-229
Mtb Structural Proteome models
Model Number1
Model nameRv2392
Template1SUR    APDBCREDO
Template coverage20_215
Template Identity(%)26.0
Model coverage(%)81.9
Normalized DOPE score-0.277

Structure Models from Chopin
Model Number1
Profilec.26.2.2 - 3.40.50.620
Click for model details
zscore33.56
Residue begin1
Residue end225
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2392Gene nameConfidence Score
Rv1286cysN0.999
Rv2391sirA0.999
Rv1286cysN0.999
Rv2391sirA0.999
Rv1286cysN0.999
Rv2847ccysG0.996
Rv2847ccysG0.996
Rv3914trxC0.986
Rv2334cysK10.976
Rv1285cysD0.966
Rv2400csubI0.965
Rv2393che10.952
Rv2007cfdxA0.941
Rv2335cysE0.906
Rv2335cysE0.906
Rv2398ccysW0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
  View results in TIBLE page
NameAffinityAssay descriptionDOI
CDD-1419970NoneNoneNone
CDD-1419976NoneNoneNone
CDD-1419996NoneNoneNone
CDD-309276NoneNoneNone
CDD-345157NoneNoneNone
CDD-345160NoneNoneNone
CDD-345161NoneNoneNone
CDD-345162NoneNoneNone
CDD-345163NoneNoneNone
CDD-9056NoneNoneNone
Off-target activity - ligand based from TIBLE
  View results in TIBLE page
Predicted off-targetMethodSummaryFull results
GTPase HRas 1P2SPharmMapper0 hydroph + 14 HB + 1 pos/neg + 0 aromLink
Sulfotransferase family cytosolic 2B member 1 1Q1ZPharmMapper0 hydroph + 8 HB + 2 pos/neg + 0 aromLink
Bile salt sulfotransferase 1OV4PharmMapper4 hydroph + 1 HB + 0 pos/neg + 0 aromLink
Tyrosine-protein phosphatase non-receptor type 1 1KAVPharmMapper4 hydroph + 3 HB + 1 pos/neg + 0 aromLink
NONE 1HFVPharmMapper0 hydroph + 11 HB + 3 pos/neg + 0 aromLink
Superoxide dismutase  PASSPa = 0.832 & SM = CDD-9056Link
CYP17  PASSPa = 0.779 & SM = CDD-1419996Link
Pyruvate decarboxylase  PASSPa = 0.749 & SM = CDD-9056Link
Leukocyte common antigen SEAE_value = 6.92e-52 & MaxTC = 0.59Link
leukocyte common antigen precursor; CD45 antigen [-] SEAE_value = 1.02e-24 & MaxTC = 0.59Link
O6-Alkylguanine-DNA Alkyltransferase Inhibitor SEAE_value = 4.42e-12 & MaxTC = 0.36Link
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
3'-phosphoadenosine 5'-phosphosulfatePubChem0.99507.264
adenosine 5'-phosphosulfatePubChem0.94427.284
sulfatePubChem0.82296.0626
3'-phosphoadenosine 5'-phosphatePubChem0.767427.201
adenosine 3',5'-diphosphatePubChem0.715427.201