SInCRe - Rv1285

Tuberculist information

Gene name	cysD
Protein function	Probable sulfate adenylyltransferase subunit 2 CysD
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	1437.91
Molecular mass(da)	37512.5
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 332

	  		  	1    MAITINMVNPTGFIRYEDVEQEAMTSDVTVGPAPGQYQLSHLRLLEAEAIHVIREVAAEF   60
			  	61   ERPVLLFSGGKDSIVMLHLALKAFRPGRLPFPVMHVDTGHNFDEVIATRDELVAAAGVRL  120
			  	121  VVASVQDDIDAGRVVETIPSRNPIQTVTLLRAIRENQFDAAFGGARRDEEKARAKERVFS  180
			  	181  FRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAEQVRLPSIYF  240
			  	241  AHRRKVFQRDGMLLAVHRHMQPRADEPVFEATVRFRTVGDVTCTGCVESSASTVAEVIAE  300
			  	301  TAVARLTERGATRADDRISEAGMEDRKRQGYF

Known structures in the PDB

No Known structures

Number of amino acids : 332

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
PAPS_reduct	PF01507	39-263

Mtb Structural Proteome models

Model Number	1
Model name	Rv1285
Template	1ZUN APDB CREDO
Template coverage	4_210
Template Identity(%)	60.6
Model coverage(%)	61.1
Normalized DOPE score	-0.467

Model Number	2
Model name	Rv1285.1
Template	1SUR APDB CREDO
Template coverage	3_211
Template Identity(%)	20.6
Model coverage(%)	73.2
Normalized DOPE score	0.508

Structure Models from Chopin

Model Number	1
Profile	c.26.2.2 Click for model details
zscore	30.64
Residue begin	36
Residue end	242

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1285	Gene name	Confidence Score
Rv1286	cysN	0.999
Rv1286	cysN	0.999
Rv1286	cysN	0.999
Rv2400c	subI	0.994
Rv2398c	cysW	0.99
Rv2399c	cysT	0.988
Rv2131c	cysQ	0.98
Rv2397c	cysA1	0.977
Rv2397c	cysA1	0.977
Rv2847c	cysG	0.97
Rv2847c	cysG	0.97
Rv2392	cysH	0.966
Rv2391	sirA	0.951
Rv2391	sirA	0.951
Rv2334	cysK1	0.914
Rv2335	cysE	0.905
Rv2335	cysE	0.905

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv1285.1	1	1uwj_BAX_A_1723 PDB CREDO	0.639	0.136	0.603	0.002
Rv1285.1	1	1uwj_BAX_B_1723 PDB CREDO	0.619	0.158	0.601	0.002
Rv1285.1	1	3d91_REM_A_350 PDB CREDO	0.594	0.186	0.577	0.003
Rv1285.1	1	3d91_REM_B_350 PDB CREDO	0.590	0.192	0.572	0.003
Rv1285.1	1	1uwh_BAX_B_1723 PDB CREDO	0.625	0.150	0.572	0.003
Rv1285.1	1	1uwh_BAX_A_1723 PDB CREDO	0.625	0.151	0.571	0.004
Rv1285.1	1	1uob_PNN_A_1311 PDB CREDO	0.595	0.185	0.561	0.004
Rv1285.1	1	1z2b_VLB_C_800 PDB CREDO	0.595	0.185	0.561	0.004
Rv1285.1	1	3ms9_STI_A_1 PDB CREDO	0.569	0.217	0.553	0.005
Rv1285.1	1	3pyy_STI_A_3 PDB CREDO	0.568	0.219	0.552	0.005
Rv1285.1	1	2hyy_STI_C_600 PDB CREDO	0.568	0.220	0.552	0.005
Rv1285.1	1	3mss_STI_A_1 PDB CREDO	0.567	0.220	0.551	0.005
Rv1285.1	1	1iep_STI_B_202 PDB CREDO	0.567	0.221	0.551	0.005
Rv1285.1	1	3k5v_STI_B_2 PDB CREDO	0.566	0.221	0.550	0.005
Rv1285.1	1	3mss_STI_C_1 PDB CREDO	0.566	0.221	0.550	0.005
Rv1285.1	1	3ms9_STI_B_1 PDB CREDO	0.566	0.222	0.550	0.005
Rv1285.1	1	2hyy_STI_A_600 PDB CREDO	0.566	0.223	0.549	0.005
Rv1285.1	1	1iep_STI_A_201 PDB CREDO	0.565	0.223	0.549	0.005
Rv1285.1	1	2hyy_STI_D_600 PDB CREDO	0.564	0.224	0.548	0.005
Rv1285.1	1	3pyy_STI_B_4 PDB CREDO	0.564	0.224	0.548	0.005
Rv1285.1	1	3mss_STI_D_1 PDB CREDO	0.561	0.229	0.545	0.005
Rv1285.1	1	3mss_STI_B_1 PDB CREDO	0.560	0.230	0.544	0.006
Rv1285.1	1	3gvu_STI_A_1001 PDB CREDO	0.559	0.231	0.543	0.006
Rv1285.1	1	3nxu_RIT_A_600 PDB CREDO	0.618	0.158	0.537	0.006
Rv1285.1	1	2x9g_LYA_A_1270 PDB CREDO	0.645	0.130	0.537	0.006
Rv1285.1	1	3b0w_DGX_A_1 PDB CREDO	0.551	0.242	0.535	0.006
Rv1285.1	1	3tne_RIT_A_401 PDB CREDO	0.623	0.153	0.535	0.006
Rv1285.1	1	3b0w_DGX_B_1 PDB CREDO	0.580	0.204	0.532	0.007
Rv1285.1	1	4asd_BAX_A_1500 PDB CREDO	0.546	0.249	0.530	0.007
Rv1285.1	1	3k5v_STI_A_2 PDB CREDO	0.577	0.208	0.529	0.007
Rv1285.1	1	2hyy_STI_B_600 PDB CREDO	0.561	0.228	0.529	0.007
Rv1285.1	1	2vn1_FK5_A_501 PDB CREDO	0.592	0.189	0.529	0.007
Rv1285.1	1	3nxu_RIT_B_600 PDB CREDO	0.608	0.169	0.528	0.007
Rv1285.1	1	3oez_STI_A_601 PDB CREDO	0.543	0.254	0.527	0.007
Rv1285.1	1	3bjw_SVR_E_503 PDB CREDO	0.616	0.160	0.521	0.008
Rv1285.1	1	3tne_RIT_B_401 PDB CREDO	0.606	0.172	0.520	0.008
Rv1285.1	1	1opj_STI_B_4 PDB CREDO	0.582	0.201	0.520	0.008
Rv1285.1	1	3ua1_08Y_A_600 PDB CREDO	0.623	0.153	0.518	0.008
Rv1285.1	1	1opj_STI_A_3 PDB CREDO	0.578	0.206	0.516	0.009
Rv1285.1	1	2oiq_STI_A_1001 PDB CREDO	0.546	0.249	0.515	0.009
Rv1285.1	1	3cs9_NIL_A_600 PDB CREDO	0.576	0.209	0.514	0.009
Rv1285.1	1	3vn2_TLS_A_501 PDB CREDO	0.579	0.205	0.513	0.009
Rv1285.1	1	2pl0_STI_A_200 PDB CREDO	0.543	0.254	0.512	0.009
Rv1285.1	1	1skx_RFP_A_1 PDB CREDO	0.584	0.199	0.507	0.010
Rv1285.1	1	1y0x_T44_X_500 PDB CREDO	0.554	0.239	0.506	0.010
Rv1285.1	1	3bjw_SVR_F_502 PDB CREDO	0.645	0.130	0.503	0.010
Rv1285.1	1	3cs9_NIL_B_600 PDB CREDO	0.578	0.206	0.502	0.011
Rv1285.1	1	3bjw_SVR_H_504 PDB CREDO	0.643	0.132	0.502	0.011
Rv1285.1	1	3kk6_CEL_B_1701 PDB CREDO	0.578	0.206	0.502	0.011
Rv1285.1	1	2w8y_486_A_1000 PDB CREDO	0.517	0.293	0.502	0.011
Rv1285.1	1	1lhv_NOG_A_301 PDB CREDO	0.602	0.176	0.501	0.011
Rv1285.1	1	3tkd_CYZ_B_267 PDB CREDO	0.548	0.246	0.501	0.011
Rv1285.1	1	3bjw_SVR_B_501 PDB CREDO	0.641	0.133	0.501	0.011
Rv1285.1	1	1fm6_BRL_X_504 PDB CREDO	0.601	0.178	0.500	0.011
Rv1285.1	1	2hw2_RFP_A_1200 PDB CREDO	0.582	0.201	0.500	0.011
Rv1285.1	1	2x9g_LYA_B_1270 PDB CREDO	0.663	0.112	0.500	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
adenosine 5'-phosphosulfatePubChem	0.982	427.284
sulfatePubChem	0.973	96.0626
3'-phosphoadenosine 5'-phosphosulfatePubChem	0.949	507.264
adenosine triphosphatePubChem	0.923	507.181
H(+)PubChem	0.9	2.01588
pyrophosphatePubChem	0.9	177.975
protiumPubChem	0.9	2.01576
adenosine 5'-phosphoselenatePubChem	0.9	474.179
adenosine diphosphatePubChem	0.9	427.201
AR-1H5400PubChem	0.9	507.264
adenosine 5'-sulphatophosphatePubChem	0.9	425.269
deuteriumPubChem	0.9	2.01588