Rv2397c

Tuberculist information
Gene namecysA1
Protein functionSulfate-transport ATP-binding protein ABC transporter CysA1
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2693.91
Molecular mass(da)37443.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 351
	  		  	1    MTYAIVVADATKRYGDFVALDHVDFVVPTGSLTALLGPSGSGKSTLLRTIAGLDQPDTGT   60
			  	61   ITINGRDVTRVPPQRRGIGFVFQHYAAFKHLTVRDNVAFGLKIRKRPKAEIKAKVDNLLQ  120
			  	121  VVGLSGFQSRYPNQLSGGQRQRMALARALAVDPEVLLLDEPFGALDAKVREELRAWLRRL  180
			  	181  HDEVHVTTVLVTHDQAEALDVADRIAVLHKGRIEQVGSPTDVYDAPANAFVMSFLGAVST  240
			  	241  LNGSLVRPHDIRVGRTPNMAVAAADGTAGSTGVLRAVVDRVVVLGFEVRVELTSAATGGA  300
			  	301  FTAQITRGDAEALALREGDTVYVRATRVPPIAGGVSGVDDAGVERVKVTST

Known structures in the PDB
PDB ID3AAX
Total residue count554
Number of chains2
MethodX-RAY
Resolution2.5
PDB ID3AAY
Total residue count554
Number of chains2
MethodX-RAY
Resolution1.9
PDB ID3HWI
Total residue count596
Number of chains2
MethodX-RAY
Resolution2.29
1 36 71 106 141 176 211 246 281 316 351 Range: 20 to 165  |  Coverage: 41% ABC_tran Range: 270 to 330  |  Coverage: 17% TOBE Range: 1 to 327  |  Coverage: 92% 1 Range: 1 to 351  |  Coverage: 99% 1 Range: 20 to 191  |  Coverage: 48% 2 Range: 1 to 272  |  Coverage: 77% 3 Range: 244 to 327  |  Coverage: 23% 4
Number of amino acids : 351
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ABC_tranPF0000520-165
TOBEPF03459270-330
Mtb Structural Proteome models
Model Number1
Model nameRv2397c
Template1Z47    APDBCREDO
Template coverage13_349
Template Identity(%)42.2
Model coverage(%)92.9
Normalized DOPE score-0.232

Structure Models from Chopin
Model Number1
Profileb.40.6.3, c.37.1.12 - 2.40.50.100, 2.40.50.140, 3.40.50.300
Click for model details
zscore61.59
Residue begin1
Residue end351
Model Number2
Profilec.37.1.12
Click for model details
zscore28.35
Residue begin20
Residue end191
Model Number3
Profilec.37.1.12
Click for model details
zscore25.57
Residue begin1
Residue end272
Model Number4
Profileb.40.6.3
Click for model details
zscore10.28
Residue begin244
Residue end327
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2397cGene nameConfidence Score
Rv2398ccysW0.999
Rv2399ccysT0.999
Rv2400csubI0.999
Rv1285cysD0.977
Rv1286cysN0.966
Rv1286cysN0.966
Rv1286cysN0.966
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
sulfatePubChem0.95596.0626
adenosine triphosphatePubChem0.912507.181
phosphatePubChem0.91296.9872
adenosine diphosphatePubChem0.907427.201
hydroxyl radicalsPubChem0.917.0073