Rv2335

Tuberculist information
Gene namecysE
Protein functionProbable serine acetyltransferase CysE (sat)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2609.73
Molecular mass(da)23770.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 229
	  		  	1    MLTAMRGDIRAARERDPAAPTALEVIFCYPGVHAVWGHRLAHWLWQRGARLLARAAAEFT   60
			  	61   RILTGVDIHPGAVIGARVFIDHATGVVIGETAEVGDDVTIYHGVTLGGSGMVGGKRHPTV  120
			  	121  GDRVIIGAGAKVLGPIKIGEDSRIGANAVVVKPVPPSAVVVGVPGQVIGQSQPSPGGPFD  180
			  	181  WRLPDLVGASLDSLLTRVARLEALGGGPQAAGVIRPPEAGIWHGEDFSI

Known structures in the PDB
No Known structures
1 23 45 67 89 111 133 155 177 199 221 Range: 71 to 108  |  Coverage: 16% Hexapep_2 Range: 117 to 152  |  Coverage: 15% Hexapep Range: 1 to 185  |  Coverage: 80% 1 Range: 1 to 187  |  Coverage: 81% 1
Number of amino acids : 229
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Hexapep_2PF1460271-108
HexapepPF00132117-152
Mtb Structural Proteome models
Model Number1
Model nameRv2335
Template1T3D    APDBCREDO
Template coverage77_262
Template Identity(%)42.7
Model coverage(%)80.3
Normalized DOPE score-1.097

Structure Models from Chopin
Model Number1
Profileb.81.1.6
Click for model details
zscore30.52
Residue begin1
Residue end187
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2335Gene nameConfidence Score
Rv2334cysK10.999
Rv1336cysM0.999
Rv1077cbs0.985
Rv1077cbs0.985
Rv0848cysK20.982
Rv3340metC0.977
Rv3580ccysS10.971
Rv3580ccysS10.971
Rv2992cgltS0.96
Rv1294thrA0.951
Rv1294thrA0.951
Rv1294thrA0.951
Rv1612trpB0.948
Rv1286cysN0.946
Rv1286cysN0.946
Rv1286cysN0.946
Rv3025ciscS0.943
Rv0070cglyA20.934
Rv1093glyA10.933
Rv3042cserB20.927
Rv3042cserB20.927
Rv1559ilvA0.924
Rv1559ilvA0.924
Rv3684Rv36840.92
Rv1613trpA0.915
Rv1079metB0.908
Rv2130cmshC0.907
Rv2392cysH0.906
Rv1285cysD0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
half-cystinePubChem0.99121.158
O-acetylserinePubChem0.978147.129
O-acetyl-L-serinePubChem0.977147.129
L-serinePubChem0.973105.093
acetyl-CoAPubChem0.97809.571
Co-APubChem0.968767.534
coenzyme APubChem0.968767.534
acetatePubChem0.96759.044
sulphurPubChem0.95234.0809
O-phosphoserinePubChem0.915185.072
phosphatePubChem0.90496.9872
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
acetyl coenzyme-APubChem0.9809.571
DL-serinePubChem0.9105.093
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576
cysteinatePubChem0.9121.158
sulfatePubChem0.86796.0626
SeMetPubChem0.796196.106
selenomethioninePubChem0.796196.106
polyethylene glycolPubChem0.78662.0678
cysteic acidPubChem0.778169.156
ethylene glycol; hydronPubChem0.77863.0758
cysteatePubChem0.778169.156
chloridePubChem0.77835.453
L-cystinePubChem0.737240.3